INT136634

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Context Info
Confidence 0.72
First Reported 2006
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 9
Total Number 14
Disease Relevance 3.34
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
neurons 2
epithelium 1
skin 1
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 66 98.72 Very High Very High Very High
Central nervous system 11 82.72 Quite High
addiction 6 81.76 Quite High
antagonist 3 74.56 Quite High
anesthesia 11 68.48 Quite High
Glutamate 9 21.60 Low Low
Hippocampus 11 11.76 Low Low
imagery 21 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
medulla 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Scrapie 145 99.96 Very High Very High Very High
Brain Hemorrhage 24 99.32 Very High Very High Very High
Injury 11 97.24 Very High Very High Very High
Infection 156 94.76 High High
Encephalopathy 75 94.36 High High
Targeted Disruption 54 93.76 High High
Cv Unclassified Under Development 48 92.16 High High
Infertility 5 92.12 High High
Prion Diseases 97 87.08 High High
Brain Injury 3 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasmid transfection and PrPC mRNA and protein analyses
Spec (analyses) Transcription (transfection) of PrPC
1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.09 Pain Relevance 0
PrP transcripts were amplified in an iCycler RT-PCR machine (Bio-Rad, Hercules, CA) using the forward primer 5?
Transcription (transcripts) of PrP
2) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.07 Pain Relevance 0
PrP mRNA expression was reported relative to that for untreated N2a cells.


Transcription (expression) of PrP
3) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0 Pain Relevance 0
WT and PrP-null mouse neurons both expressed NR2D subunit mRNA and protein, with ?
Transcription (expressed) of PrP in neurons
4) Confidence 0.69 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0.04
Interestingly, compared to control cells, a higher amount of PrPSc was observed to colocalize with Tfn in the ERC of transfected cells (Figure 7A lower panels) indicating that PrP was also retained in this compartment.
Transcription (amount) of PrPSc
5) Confidence 0.68 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
RT-PCR analysis of Prnp transcription after transient focal cerebral ischemia
Transcription (transcription) of Prnp associated with brain hemorrhage and ischemia
6) Confidence 0.63 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.52 Pain Relevance 0.26
We observed that 23-230 PrP interacts with chromatin in vivo, as already described for recombinant PrP and for PrPSc.
Transcription (described) of PrPSc
7) Confidence 0.60 Published 2006 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 16806967 Disease Relevance 0.14 Pain Relevance 0.07
We observed that 23-230 PrP interacts with chromatin in vivo, as already described for recombinant PrP and for PrPSc.
Transcription (described) of PrP
8) Confidence 0.60 Published 2006 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 16806967 Disease Relevance 0.14 Pain Relevance 0.07
Moreover, using in situ hybridization an increase of PrP mRNA levels and also PrP immunoreactivity were detected in penumbral neurons of the ischemic lesion (21).
Transcription (levels) of PrP in neurons
9) Confidence 0.53 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.71 Pain Relevance 0.05
RT-PCR (figure 1B) and FACS analyses (figure 1C and D) demonstrate that all three shRNA plasmids suppressed PrP mRNA and protein levels, respectively, in a dose-dependent manner, to less than 25% of normal levels (p<0.01, n?
Transcription (levels) of PrP
10) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.14 Pain Relevance 0
Cells were harvested 48 hours later and analyzed for PrPC mRNA and protein expression. mRNA was isolated using the Oligotex Direct mRNA mini kit reverse-transcription polymerase chain reaction (RT-PCR) performed in real-time using QuantiTect SYBR Green RT-PCR Kit (Qiagen).
Spec (analyzed) Transcription (expression.) of PrPC
11) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.08 Pain Relevance 0
In hamsters fed with scrapie, PrPSc was detected before the onset of symptoms, but the bulk of skin-associated PrPSc accumulated in the clinical phase.
Transcription (detected) of PrPSc in skin associated with scrapie
12) Confidence 0.53 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1876502 Disease Relevance 0.51 Pain Relevance 0.08
Transcription levels of Prnp from these areas were analyzed by QRT-PCR and were compared with the corresponding ipsilateral (I) and the contralateral hemispheres (C) of sham-operated animals (Figure 3B).
Spec (analyzed) Transcription (Transcription) of Prnp
13) Confidence 0.47 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.57 Pain Relevance 0.26
Like the olfactory epithelium, the VNO epithelium has both a sensory and non-sensory epithelium, but PrPSc deposition was only detected in the sensory epithelium of the VNO.
Transcription (detected) of PrPSc in epithelium
14) Confidence 0.45 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.36 Pain Relevance 0

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