INT136653

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.29
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
peripheral nervous system 1
TFP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 15 100.00 Very High Very High Very High
Peripheral nervous system 3 99.68 Very High Very High Very High
analgesia 3 96.44 Very High Very High Very High
local anesthetic 9 75.00 Quite High
Nav1.7 3 75.00 Quite High
Sciatic nerve 3 36.96 Quite Low
Regional anesthesia 3 25.00 Low Low
Analgesic 3 25.00 Low Low
Pain management 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 3 98.72 Very High Very High Very High
Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We asked whether TFP could modulate the Na(v)1.7 sodium channel, which is highly expressed in the peripheral nervous system and plays an important role in nociception.
Gene_expression (expressed) of TFP in peripheral nervous system associated with nociception, peripheral nervous system and sodium channel
1) Confidence 0.39 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16807347 Disease Relevance 0.10 Pain Relevance 0.45
We show that 500 nM and 2 muM TFP induce major decreases in Na(v)1.7 and Na(v)1.4 current amplitudes and that 2 muM TFP causes hyperpolarizing shifts in the steady-state inactivation of Na(v)1.7 and Na(v)1.4.
Gene_expression (induce) of TFP
2) Confidence 0.30 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16807347 Disease Relevance 0.10 Pain Relevance 0.45
We show that 500 nM and 2 muM TFP induce major decreases in Na(v)1.7 and Na(v)1.4 current amplitudes and that 2 muM TFP causes hyperpolarizing shifts in the steady-state inactivation of Na(v)1.7 and Na(v)1.4.
Gene_expression (causes) of TFP
3) Confidence 0.30 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16807347 Disease Relevance 0.10 Pain Relevance 0.45

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox