INT136664

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 49
Total Number 49
Disease Relevance 25.91
Pain Relevance 5.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) nucleus (Twist1) DNA binding (Twist1)
transcription factor binding (Twist1)
Anatomy Link Frequency
Th1 cells 16
T cells 6
Th2 cells 4
leg 2
gut 2
Twist1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 803 99.70 Very High Very High Very High
rheumatoid arthritis 128 99.64 Very High Very High Very High
Inflammation 1366 99.60 Very High Very High Very High
Pain 5 98.20 Very High Very High Very High
Crohn's disease 224 97.98 Very High Very High Very High
Migraine 4 97.12 Very High Very High Very High
Arthritis 480 96.76 Very High Very High Very High
headache 2 96.76 Very High Very High Very High
trigeminal ganglion 4 93.60 High High
Inflammatory response 48 88.56 High High
Disease Link Frequency Relevance Heat
Cancer 1652 100.00 Very High Very High Very High
Rheumatoid Arthritis 192 99.64 Very High Very High Very High
INFLAMMATION 1422 99.60 Very High Very High Very High
Melanoma 27 99.28 Very High Very High Very High
Death 70 98.36 Very High Very High Very High
Pressure And Volume Under Development 74 98.32 Very High Very High Very High
Pain 5 98.20 Very High Very High Very High
Disease 470 97.98 Very High Very High Very High
Stress 43 97.88 Very High Very High Very High
Necrosis 57 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S3, available at http://www.jem.org/cgi/content/full/jem.20072468/DC1), but also did not induce twist1 expression in activated Th2 cells, as described in Fig. 1.
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of twist1 in Th2 cells
1) Confidence 0.69 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Their imprinting for increased twist1 expression, maintained over time in individual patients, indicates a history of repeated restimulation and an endogenous regulation of proinflammatory effector functions under the control of NFAT and NF-?
Positive_regulation (increased) of Gene_expression (expression) of twist1
2) Confidence 0.69 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.09 Pain Relevance 0.05
Ectopic overexpression of twist1 in 6-d-old Th1 cells, which still had a low endogenous expression level, drastically reduced their pathogenic contribution to DTH.
Positive_regulation (overexpression) of Gene_expression (overexpression) of twist1 in Th1 cells associated with hypersensitivity
3) Confidence 0.69 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.58 Pain Relevance 0.40
The requirement of NFAT for induction of twist1 expression in Th1 cells distinguishes control of twist1 expression in Th cells from its control in fibroblasts, where TNF-?
Positive_regulation (induction) of Gene_expression (expression) of twist1 in Th1 cells
4) Confidence 0.69 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Thus, imprinting for enhanced twist1 expression is a hallmark of repeatedly restimulated Th1 memory cells.
Positive_regulation (imprinting) of Gene_expression (expression) of twist1
5) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.35 Pain Relevance 0.12
during the primary activation of Th cells in the absence of IL-12 did not suffice to induce twist1 expression (Fig.
Positive_regulation (induce) of Gene_expression (expression) of twist1
6) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.15 Pain Relevance 0.07
Adoptive transfer of Th1 cells versus Th1 cells with a shRNA-mediated knockdown of twist1 expression demonstrates the relevance of twist1 expression by Th1 cells for the control of immunopathology.
Positive_regulation (relevance) of Gene_expression (expression) of twist1 in Th1 cells
7) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.68 Pain Relevance 0.29
Twist1 expression was enhanced by five- to eightfold in CD3+B220+ T cells from MRL/lpr mice, which represent chronically activated T lymphocytes (24, 25).
Positive_regulation (enhanced) of Gene_expression (expression) of Twist1 in T lymphocytes
8) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.09 Pain Relevance 0
Expression of twist1 in Th cells is induced by IL-12/STAT4, NF-?
Positive_regulation (by) of Gene_expression (Expression) of twist1
9) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.69 Pain Relevance 0.30
Th1 effector memory (EM) cells (18) show increased transient reexpression of twist1 upon T cell receptor engagement.
Positive_regulation (increased) of Gene_expression (reexpression) of twist1 in T cell
10) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.95 Pain Relevance 0.33
Expression of twist1 follows TCR stimulation transiently and increases upon repeated stimulation.
Positive_regulation (increases) of Gene_expression (Expression) of twist1
11) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.42 Pain Relevance 0.16
B (20) but not NFAT, did not induce twist1 expression, whereas PMA in combination with the NFAT-activating ionomycin did (Fig. 3 C).
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of twist1
12) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Expression of twist1 increases upon repeated restimulation in vitro in Th1 cells, whereas it is not induced even in repeatedly restimulated Th2 or Th17 cells.
Positive_regulation (increases) of Gene_expression (Expression) of twist1 in Th1 cells
13) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.17 Pain Relevance 0.09
Twist1 expression is enhanced in CCR7?
Positive_regulation (enhanced) of Gene_expression (expression) of Twist1
14) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
For the initial expression of twist1 in Th1 cells, and its imprinting for reexpression in further restimulations, the concerted action of activated STAT4, NFAT1, and NF-?
Positive_regulation (initial) of Gene_expression (expression) of twist1 in Th1 cells
15) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Imprinting of the twist1 gene for reexpression in Th1 cells is reflected by increased acetylation of histone H3 and trimethylated histone H3 at lysine 4, in both resting and reactivated Th1 cells, as compared with Th2 cells (Fig.
Positive_regulation (reactivated) of Gene_expression (reexpression) of twist1 in Th2 cells
16) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.05 Pain Relevance 0
Thus, imprinting for enhanced twist1 expression is a hallmark of repeatedly restimulated Th1 memory cells.
Positive_regulation (enhanced) of Gene_expression (expression) of twist1
17) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.30 Pain Relevance 0.12
B are required for induction of twist1 expression in Th1 cells.
Positive_regulation (induction) of Gene_expression (expression) of twist1 in Th1 cells
18) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
and STAT1 signaling did not induce twist1 expression in the absence of IL-12 (Fig. 2 A).
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of twist1
19) Confidence 0.46 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Genes differentially expressed upon ectopic twist1 overexpression are listed in Table S3.
Positive_regulation (overexpression) of Gene_expression (overexpression) of twist1
20) Confidence 0.46 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.35 Pain Relevance 0.22

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