INT136672

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 15
Disease Relevance 4.46
Pain Relevance 4.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Cnga1) cytoplasm (Cnga1)
Anatomy Link Frequency
dorsal root ganglion 2
spinal nerves 1
respiratory system 1
neurons 1
granulosa cells 1
Cnga1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 30 99.92 Very High Very High Very High
Eae 4 99.22 Very High Very High Very High
c fibre 6 99.00 Very High Very High Very High
Analgesic 6 98.76 Very High Very High Very High
Pain 11 98.48 Very High Very High Very High
anticonvulsant 3 98.46 Very High Very High Very High
Gabapentin 6 98.08 Very High Very High Very High
intrathecal 6 98.00 Very High Very High Very High
Migraine 4 97.40 Very High Very High Very High
dorsal root ganglion 10 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 7 99.88 Very High Very High Very High
Injury 4 99.22 Very High Very High Very High
Pain 7 98.48 Very High Very High Very High
Migraine Disorders 1 97.40 Very High Very High Very High
Ganglion Cysts 23 97.04 Very High Very High Very High
Hyperalgesia 4 97.04 Very High Very High Very High
Neuropathic Pain 18 96.68 Very High Very High Very High
Nervous System Injury 4 75.00 Quite High
Diabetic Neuropathy 1 66.40 Quite High
Aging 49 61.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the chronic constriction injury (CCI) model, we found abundant axonal accumulation of HCN channel protein at the injured sites accompanied by a slight decrease in DRG neuronal bodies.
Positive_regulation (accumulation) of HCN in DRG associated with dorsal root ganglion, eae and injury
1) Confidence 0.58 Published 2008 Journal Pain Section Abstract Doc Link 18179873 Disease Relevance 1.44 Pain Relevance 1.21
This suggests that modulation of cAMP and cGMP levels by PDE and activation of CNG may play a role in trigeminovascular pain signalling leading to migraine headache.
Positive_regulation (activation) of CNG associated with pain, migraine and headache
2) Confidence 0.56 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16808996 Disease Relevance 0.54 Pain Relevance 0.49
BACKGROUND AND OBJECTIVE: Gabapentin, an anticonvulsant with analgesic effect, has been reported to be an activator of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
Positive_regulation (activator) of HCN associated with analgesic, anticonvulsant and gabapentin
3) Confidence 0.44 Published 2009 Journal Eur J Anaesthesiol Section Abstract Doc Link 19322095 Disease Relevance 0 Pain Relevance 0.55
CONCLUSION: Our data suggest that activation of spinal or dorsal root ganglion HCN channels or both is not involved in formalin-induced pain, and intrathecal gabapentin does not act as an HCN channel activator to achieve its antinociceptive effect in the formalin test.


Positive_regulation (activation) of HCN in dorsal root ganglion
4) Confidence 0.41 Published 2009 Journal Eur J Anaesthesiol Section Body Doc Link 19322095 Disease Relevance 0 Pain Relevance 0
These results suggest that axonal HCN channel accumulation plays an important role in ectopic discharges from injured spinal nerves and contributes to the development of mechanical allodynia in neuropathic pain rats.
Positive_regulation (accumulation) of HCN in spinal nerves associated with allodynia and neuropathic pain
5) Confidence 0.39 Published 2008 Journal Pain Section Abstract Doc Link 18179873 Disease Relevance 1.32 Pain Relevance 1.08
This effect was attributable to a depolarizing shift in the voltage dependence of HCN channel activation (Fig. 6C).
Positive_regulation (activation) of HCN associated with addiction
6) Confidence 0.39 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0.05
During the application of NO, there was also a decrease in input resistance during this long hyperpolarizing current injection (Rinput; Fig. 4H and J), as expected from increased HCN channel activation.
Positive_regulation (activation) of HCN
7) Confidence 0.39 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0.07
In granulosa cells it is possible that hyperpolarization of the cell membrane could activate HCN channels, thereby resulting in membrane depolarization.
Positive_regulation (activate) of HCN in granulosa cells
8) Confidence 0.35 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.11 Pain Relevance 0.19
m) there was an apparent reversible enhancement of HCN channel function.
Positive_regulation (enhancement) of HCN
9) Confidence 0.28 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0.05
In addition, whole-cell patch-clamp data revealed diabetes also increased HCN currents in A-fiber and C-fiber neurons.
Positive_regulation (increased) of HCN in neurons associated with c fibre and diabetes mellitus
10) Confidence 0.27 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.00 Pain Relevance 0.76
To follow the progress of wash-in (and wash-out), a small (approximately 40 mV), short (typically 500 ms) hyperpolarizing step (such as illustrated in Fig. 6A and B) from the holding potential was applied every 10 s to activate sufficient HCN channels to monitor changes.
Positive_regulation (activate) of HCN
11) Confidence 0.26 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0
Given the evidence that endogenous NO regulates axonal function in the optic nerve through cGMP and a subsequent activation of HCN channels (Garthwaite et al., 2006), the present investigation aimed to test directly if HCN channels may be considered more general targets for NO-cGMP signalling in neurones, bearing in mind that the channels are commonly viewed as being modulated primarily by cAMP (DiFrancesco & Tortora, 1991; Ludwig et al., 1998; Zagotta et al., 2003).
Positive_regulation (activation) of HCN in optic nerve
12) Confidence 0.26 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0
In contrast to most voltage gated channels, HCN channels are activated by membrane hyperpolarization [16-19].
Positive_regulation (activated) of HCN
13) Confidence 0.23 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.05 Pain Relevance 0.17
There is a cyclic nucleotide-binding domain (CNDB) on the C-terminal of each HCN channel subunit, and the binding of cAMP directly facilitates activation of HCN channels [20].
Positive_regulation (activation) of HCN
14) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948503 Disease Relevance 0 Pain Relevance 0
AITC may have a different mode of action on the respiratory system than HCN and rotenone as the CO2 production of P. americana was significantly increased by AITC as compared to the control (Fig. 3).
Positive_regulation (increased) of HCN in respiratory system
15) Confidence 0.05 Published 2002 Journal BMC Ecol Section Body Doc Link PMC102324 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox