INT136675

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Context Info
Confidence 0.63
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.74
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
spinal cord 2
trigeminal ganglion 1
dorsal root ganglion 1
Pde5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 8 99.84 Very High Very High Very High
dorsal root ganglion 4 99.84 Very High Very High Very High
Brush evoked pain 24 99.38 Very High Very High Very High
antiallodynic 4 97.58 Very High Very High Very High
trigeminal ganglion 4 97.24 Very High Very High Very High
Migraine 4 78.24 Quite High
headache 3 77.28 Quite High
Pain 2 67.88 Quite High
Analgesic 4 25.00 Low Low
Inflammation 38 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 24 99.38 Very High Very High Very High
Ganglion Cysts 8 99.36 Very High Very High Very High
Diabetes Mellitus 32 99.24 Very High Very High Very High
Polyuria 4 98.60 Very High Very High Very High
Headache 5 78.24 Quite High
Pain 2 67.88 Quite High
INFLAMMATION 44 5.00 Very Low Very Low Very Low
Pulmonary Disease 31 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Hypertension 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDE3A, PDE3B, and PDE5A mRNA were detected in all tissues examined except for PDE3A mRNA in dura mater and the trigeminal ganglion.
Transcription (detected) of PDE5A in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
1) Confidence 0.63 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16808996 Disease Relevance 0.71 Pain Relevance 0.54
The possible antiallodynic effect of phosphodiesterase 5 inhibitor sildenafil and nitric oxide donor glyceryl trinitrate as well as the changes in phosphodiesterase 5A2 mRNA expression in dorsal root ganglion and spinal cord of allodynic diabetic rats was assessed.
Transcription (expression) of phosphodiesterase 5A2 in spinal cord associated with ganglion cysts, dorsal root ganglion, diabetes mellitus, antiallodynic and spinal cord
2) Confidence 0.51 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20079349 Disease Relevance 0.83 Pain Relevance 0.46
Streptozotocin injection produced hyperlglycemia, polydipsia, polyphagia and polyuria as well as long-term tactile allodynia (12 weeks) and a reduction of phosphodiesterase 5A2 mRNA expression in spinal cord of diabetic rats.
Transcription (expression) of phosphodiesterase 5A2 in spinal cord associated with brush evoked pain, polyuria, diabetes mellitus and spinal cord
3) Confidence 0.51 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20079349 Disease Relevance 1.17 Pain Relevance 0.59
Moreover, both drugs reversed streptozotocin-induced phosphodiesterase 5A2 mRNA expression reduction.
Transcription (expression) of phosphodiesterase 5A2
4) Confidence 0.38 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20079349 Disease Relevance 1.21 Pain Relevance 0.66
The regulatory domains include the calmodulin binding domain found in PDE1, the cGMP binding (GAF) domains found in PDE2, 5, 6, 10, and 11, and the so called upstream conserved regions 1 and 2 (UCR1 and UCR2) found in PDE4.
Transcription (found) of cGMP
5) Confidence 0.18 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
The possible antiallodynic effect of phosphodiesterase 5 inhibitor sildenafil and nitric oxide donor glyceryl trinitrate as well as the changes in phosphodiesterase 5A2 mRNA expression in dorsal root ganglion and spinal cord of allodynic diabetic rats was assessed.
Transcription (expression) of phosphodiesterase 5A2 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, diabetes mellitus, antiallodynic and spinal cord
6) Confidence 0.17 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20079349 Disease Relevance 0.83 Pain Relevance 0.46

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