INT136678

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.93
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Shc1) aging (Shc1) plasma membrane (Shc1)
nucleus (Shc1) cytoplasm (Shc1)
Anatomy Link Frequency
hippocampus 4
Shc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 18 100.00 Very High Very High Very High
Hippocampus 4 100.00 Very High Very High Very High
Pain threshold 3 99.24 Very High Very High Very High
tail-flick 2 77.08 Quite High
Inflammation 96 42.72 Quite Low
Osteoarthritis 60 5.00 Very Low Very Low Very Low
rheumatoid arthritis 48 5.00 Very Low Very Low Very Low
cytokine 30 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 13 100.00 Very High Very High Very High
Lifespan 4 100.00 Very High Very High Very High
Pain 15 99.24 Very High Very High Very High
Nociception 1 90.52 High High
Cognitive Disorder 4 86.64 High High
Sprains And Strains 1 82.84 Quite High
Aging 4 81.44 Quite High
Targeted Disruption 1 81.16 Quite High
Apoptosis 102 74.80 Quite High
INFLAMMATION 93 42.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deletion of the p66 gene results in an increase in pain threshold and reduced emotionality, differences with wild-type subjects becoming more pronounced with age.
Positive_regulation (results) of Gene_expression (Deletion) of p66 associated with pain threshold
1) Confidence 0.50 Published 2007 Journal Exp. Gerontol. Section Abstract Doc Link 16809014 Disease Relevance 0.91 Pain Relevance 0.35
Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Positive_regulation (increases) of Gene_expression (Deletion) of p66 in hippocampus associated with stress, pain, lifespan and hippocampus
2) Confidence 0.50 Published 2008 Journal Exp. Gerontol. Section Title Doc Link 18065182 Disease Relevance 0.81 Pain Relevance 0.53
Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Positive_regulation (increases) of Gene_expression (Deletion) of Shc in hippocampus associated with stress, pain, lifespan and hippocampus
3) Confidence 0.50 Published 2008 Journal Exp. Gerontol. Section Title Doc Link 18065182 Disease Relevance 0.81 Pain Relevance 0.53
1-integrin and activation of Shc, ERK 1/2 and Sox-9.
Positive_regulation (activation) of Gene_expression (/) of Shc
4) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.31 Pain Relevance 0
Further, in these cultures the chondrogenic signalling cascade was activated with high expression of Shc, activated ERK 1/2 and Sox-9.
Positive_regulation (activated) of Gene_expression (expression) of Shc
5) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.05 Pain Relevance 0
Further, in these cultures the chondrogenic signalling cascade was activated with high expression of Shc, activated ERK 1/2 and Sox-9.
Positive_regulation (activated) of Gene_expression (expression) of Shc
6) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.05 Pain Relevance 0

General Comments

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