INT136680

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 3.36
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Shc1) aging (Shc1) plasma membrane (Shc1)
nucleus (Shc1) cytoplasm (Shc1)
Anatomy Link Frequency
hippocampus 4
heart 2
Shc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 12 100.00 Very High Very High Very High
Hippocampus 4 98.28 Very High Very High Very High
ischemia 4 76.08 Quite High
tail-flick 2 74.36 Quite High
Pain threshold 3 62.56 Quite High
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 4 100.00 Very High Very High Very High
Stress 23 99.16 Very High Very High Very High
Pain 9 98.20 Very High Very High Very High
Aging 15 95.40 Very High Very High Very High
Cognitive Disorder 4 83.92 Quite High
Targeted Disruption 3 83.76 Quite High
Atherosclerosis 6 82.08 Quite High
Sprains And Strains 1 82.00 Quite High
Cv Unclassified Under Development 4 76.08 Quite High
Death 2 74.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice.
Negative_regulation (prevents) of Gene_expression (Deletion) of p66Shc associated with pain
1) Confidence 0.43 Published 2007 Journal Exp. Gerontol. Section Title Doc Link 16809014 Disease Relevance 0.86 Pain Relevance 0.38
Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Negative_regulation (decreases) of Gene_expression (Deletion) of p66 in hippocampus associated with stress, pain, lifespan and hippocampus
2) Confidence 0.43 Published 2008 Journal Exp. Gerontol. Section Title Doc Link 18065182 Disease Relevance 0.78 Pain Relevance 0.52
Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Negative_regulation (decreases) of Gene_expression (Deletion) of Shc in hippocampus associated with stress, pain, lifespan and hippocampus
3) Confidence 0.43 Published 2008 Journal Exp. Gerontol. Section Title Doc Link 18065182 Disease Relevance 0.78 Pain Relevance 0.52
More recent studies have observed that absence of p66Shc expression might contribute to the protection of the heart from the deleterious effects of elevated Angiotensis II levels [9].
Negative_regulation (absence) of Gene_expression (expression) of p66Shc in heart
4) Confidence 0.43 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.93 Pain Relevance 0.14

General Comments

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