INT136681

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Context Info
Confidence 0.77
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 9.67
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Shc1) aging (Shc1) plasma membrane (Shc1)
nucleus (Shc1) cytoplasm (Shc1)
Anatomy Link Frequency
hippocampus 2
lymphocytes 1
heart 1
Shc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 30 100.00 Very High Very High Very High
Pain threshold 6 98.72 Very High Very High Very High
Hippocampus 8 95.96 Very High Very High Very High
ischemia 17 92.04 High High
tail-flick 4 72.04 Quite High
Inflammation 98 58.72 Quite High
Osteoarthritis 60 5.00 Very Low Very Low Very Low
rheumatoid arthritis 48 5.00 Very Low Very Low Very Low
cytokine 30 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 30 100.00 Very High Very High Very High
Pain 24 98.72 Very High Very High Very High
Atherosclerosis 24 98.04 Very High Very High Very High
Stress 159 97.84 Very High Very High Very High
Apoptosis 109 95.68 Very High Very High Very High
Aging 89 95.04 Very High Very High Very High
Cv Unclassified Under Development 17 92.04 High High
Death 16 90.56 High High
Nociception 2 90.52 High High
Targeted Disruption 45 83.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering the recent observations that alterations in expression of p66Shc gene might be one possible cause in determining life span and in controlling oxidative stress, we hypothesised that sequence variations in p66Shc promoter may contribute to both aging and early atherogenesis.
Gene_expression (expression) of p66Shc associated with stress, aging and atherosclerosis
1) Confidence 0.77 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.88 Pain Relevance 0
Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice.
Gene_expression (Deletion) of p66Shc associated with pain
2) Confidence 0.68 Published 2007 Journal Exp. Gerontol. Section Title Doc Link 16809014 Disease Relevance 0.86 Pain Relevance 0.38
Deletion of the p66 gene results in an increase in pain threshold and reduced emotionality, differences with wild-type subjects becoming more pronounced with age.
Gene_expression (Deletion) of p66 associated with pain threshold
3) Confidence 0.68 Published 2007 Journal Exp. Gerontol. Section Abstract Doc Link 16809014 Disease Relevance 0.90 Pain Relevance 0.35
Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Gene_expression (Deletion) of p66 in hippocampus associated with stress, pain, lifespan and hippocampus
4) Confidence 0.68 Published 2008 Journal Exp. Gerontol. Section Title Doc Link 18065182 Disease Relevance 0.76 Pain Relevance 0.51
Deletion of the p66(Shc) gene in mice results in reduced levels of oxidative stress and longer lifespan.
Gene_expression (Deletion) of Shc associated with stress and lifespan
5) Confidence 0.68 Published 2008 Journal Exp. Gerontol. Section Abstract Doc Link 18065182 Disease Relevance 0.49 Pain Relevance 0.13
Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Gene_expression (Deletion) of Shc in hippocampus associated with stress, pain, lifespan and hippocampus
6) Confidence 0.68 Published 2008 Journal Exp. Gerontol. Section Title Doc Link 18065182 Disease Relevance 0.76 Pain Relevance 0.51
Deletion of the p66(Shc) gene in mice results in reduced levels of oxidative stress and longer lifespan.
Gene_expression (Deletion) of p66 associated with stress and lifespan
7) Confidence 0.68 Published 2008 Journal Exp. Gerontol. Section Abstract Doc Link 18065182 Disease Relevance 0.49 Pain Relevance 0.13
More recent studies have observed that absence of p66Shc expression might contribute to the protection of the heart from the deleterious effects of elevated Angiotensis II levels [9].
Gene_expression (expression) of p66Shc in heart
8) Confidence 0.59 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.93 Pain Relevance 0.14
In this regard, it has been reported that histone deacetylase inhibitors and demethylating agents restore p66Shc expression in human peripheral blood lymphocytes (PBL) that normally do not express this isoform [8].
Gene_expression (expression) of p66Shc in lymphocytes
9) Confidence 0.59 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 1.03 Pain Relevance 0.15
p66Shc expression is tissue specific [7] and it is regulated by epigenetic modifications, namely histone deacetylation and cytosine methylation.
Gene_expression (expression) of p66Shc
10) Confidence 0.59 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 1.05 Pain Relevance 0.17
Mice lacking expression of p66shc live 30% longer than wild-type mice (Migliaccio et al. 1999).
Gene_expression (expression) of p66shc
11) Confidence 0.42 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.85 Pain Relevance 0
The GenBank (http://www.ncbi.nlm.nih.gov/Genbank/) RefSeq accession numbers for the genes discussed in this paper are as follows: Adcyap1r1 (NM_001025372.1), Atp2b1 (NM_026482.1), D4Ertd22e (NM_174996.2), Dnalc4 (NM_017470.1), Gtl3 (NM_008187.1), Ilf3 (NM_001042708.1), Ktn1 (NM_008477.1), Nf2 (NM_010898.2), Pitpnb (NM_019640.2), Rabggtb (NM_011231.1), Rnf14 (NM_020012.1), Samhd1 (NM_018851.2), Shc1 (NM_011368.3), Spna2 (NM_001076554.1), Timm22 (NM_019818.2), U26 (NM_173765.1), and Xpo4 (NM_020506.1).



Gene_expression (follows) of Shc1
12) Confidence 0.37 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0 Pain Relevance 0
Further, in these cultures the chondrogenic signalling cascade was activated with high expression of Shc, activated ERK 1/2 and Sox-9.
Gene_expression (expression) of Shc
13) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.05 Pain Relevance 0
1-integrin was upregulated and Shc, activated ERK 1/2 and the chondrogenic specific transcription factor Sox-9 was highly expressed in MSC cultures treated with IL-1?
Gene_expression (expressed) of Shc
14) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.31 Pain Relevance 0.03
1-integrin and activation of Shc, ERK 1/2 and Sox-9.
Gene_expression (/) of Shc
15) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.30 Pain Relevance 0

General Comments

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