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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.58
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
macrophages 2
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 2 100.00 Very High Very High Very High
Eae 2 98.96 Very High Very High Very High
Inflammation 24 98.52 Very High Very High Very High
psoriasis 11 98.40 Very High Very High Very High
Bile 1 87.04 High High
Etanercept 2 75.00 Quite High
rheumatoid arthritis 2 68.40 Quite High
spinal inflammation 1 65.92 Quite High
cytokine 4 65.28 Quite High
Inflammatory mediators 2 59.80 Quite High
Disease Link Frequency Relevance Heat
Necrosis 5 100.00 Very High Very High Very High
Cancer 5 100.00 Very High Very High Very High
Neuropathic Pain 2 100.00 Very High Very High Very High
INFLAMMATION 25 98.52 Very High Very High Very High
Psoriasis 14 98.40 Very High Very High Very High
Injury 3 98.12 Very High Very High Very High
Obesity 7 96.08 Very High Very High Very High
Hepatopulmonary Syndrome 14 94.32 High High
Cirrhosis 61 83.76 Quite High
Pressure And Volume Under Development 33 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
STUDY DESIGN: The effects of a low, local dose of a tumor necrosis factor-alpha (TNF-alpha) inhibitor on neuropathic pain behaviors in a rat chronic constriction injury model were evaluated.
Regulation (effects) of Negative_regulation (inhibitor) of TNF-alpha associated with necrosis, cancer, eae, injury and neuropathic pain
1) Confidence 0.45 Published 2008 Journal Spine Section Abstract Doc Link 18303453 Disease Relevance 0.70 Pain Relevance 0.30
Bupivacaine was effective in suppressing systemic tumor necrosis factor alpha and interleukin 1beta by all three routes, whereas tetrodotoxin was ineffective by all three routes.
Regulation (effective) of Negative_regulation (suppressing) of tumor necrosis factor alpha
2) Confidence 0.45 Published 2006 Journal Anesthesiology Section Body Doc Link 16810004 Disease Relevance 0.12 Pain Relevance 0
appears to have a significant role in the accumulation of intravascular macrophages in CBDL animal models; inhibition of TNF-?
Regulation (role) of Negative_regulation (inhibition) of TNF in macrophages
3) Confidence 0.44 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003209 Disease Relevance 0.87 Pain Relevance 0.04
Tumor necrosis factor-alpha (TNFalpha) inhibition is effective in the treatment of moderate-to-severe psoriasis.
Regulation (effective) of Negative_regulation (inhibition) of Tumor necrosis factor-alpha associated with psoriasis, necrosis and cancer
4) Confidence 0.10 Published 2008 Journal Am J Clin Dermatol Section Abstract Doc Link 18092839 Disease Relevance 1.12 Pain Relevance 0.25
PMFs regulated levels of adipocytokines through suppression of TNF-alpha, interferon-gamma, IL-1 beta and IL-6 expression [22].
Regulation (regulated) of Negative_regulation (suppression) of TNF-alpha
5) Confidence 0.05 Published 2009 Journal Nutr J Section Body Doc Link PMC2739863 Disease Relevance 0.77 Pain Relevance 0.20

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