INT136720

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.99
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PRSS2) extracellular space (PRSS2) extracellular region (PRSS2)
Anatomy Link Frequency
TMJ 2
acinar cells 1
PRSS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 12 99.70 Very High Very High Very High
alcohol 10 96.76 Very High Very High Very High
metalloproteinase 12 95.16 Very High Very High Very High
Chronic pancreatitis 9 80.72 Quite High
antagonist 1 33.76 Quite Low
Somatostatin 1 30.68 Quite Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 12 99.70 Very High Very High Very High
Pancreatic Cancer 73 99.50 Very High Very High Very High
Adenocarcinoma 67 92.72 High High
Islet Cell Adenoma 29 91.96 High High
Cancer 61 89.44 High High
Choledocholithiasis 8 81.32 Quite High
Pancreatitis 19 80.72 Quite High
Thyroid Neoplasm 1 77.88 Quite High
Skin Cancer 1 75.84 Quite High
Leukemia 2 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes encoding digestive enzymes produced by acinar cells such as amylase (AMY2A), elastase (ELA3A, ELA3B), carboxypeptidase A (CPA2), pancreatic lipase (PNLIP), and trypsin (PRSS2) were enriched in this cluster (Figures 1, “Acinar” cluster).
Gene_expression (produced) of PRSS2 in acinar cells
1) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.17 Pain Relevance 0.07
Hyperexpression of the PRSS2 gene and hypermethylation of ELA3B gene promoter were associated with PC, raising the possibility of their application as new biomarkers in PC diagnosis and screening.
Gene_expression (Hyperexpression) of PRSS2 gene associated with pancreatic cancer
2) Confidence 0.39 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20428826 Disease Relevance 1.11 Pain Relevance 0.06
In PC tissues compared to PN, levels of PRSS2 mRNA were significantly higher, ELA3B significantly lower, and PLRP1 and CTRB not significantly different.
Gene_expression (levels) of PRSS2 mRNA associated with pancreatic cancer
3) Confidence 0.39 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20428826 Disease Relevance 1.78 Pain Relevance 0.26
Its right half ('healthy tissues') displays genes already discussed for the overview such as PPY, PNLIP and PRSS2, which are expressed by healthy pancreatic cells for food digestion and which are downregulated upon alcohol consumption (both past and present).
Gene_expression (expressed) of PRSS2 associated with alcohol
4) Confidence 0.15 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1774576 Disease Relevance 0.29 Pain Relevance 0.17
This study demonstrated that TMJ fibroblasts can predominantly utilize a serine proteinase to mediate collagen degradation, which is not trypsinogen-2.
Gene_expression (utilize) of trypsinogen-2 in TMJ associated with snapping jaw
5) Confidence 0.03 Published 2006 Journal Biochim. Biophys. Acta Section Abstract Doc Link 16814470 Disease Relevance 0.32 Pain Relevance 0.40
Reverse transcript-PCR and real-time PCR results demonstrated that TMJ cells did not express trypsinogen-2 mRNA, a collagen cleaving serine proteinase.
Neg (not) Gene_expression (express) of trypsinogen-2 in TMJ associated with snapping jaw
6) Confidence 0.03 Published 2006 Journal Biochim. Biophys. Acta Section Abstract Doc Link 16814470 Disease Relevance 0.33 Pain Relevance 0.46

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