INT13674

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Context Info
Confidence 0.65
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 2.22
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cyp1a1) mitochondrion (Cyp1a1) oxidoreductase activity (Cyp1a1)
aging (Cyp1a1) endoplasmic reticulum (Cyp1a1) enzyme binding (Cyp1a1)
Anatomy Link Frequency
hepatocytes 1
kidney 1
Cyp1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dismenorea 4 99.52 Very High Very High Very High
Paracetamol 7 99.12 Very High Very High Very High
endometriosis 4 98.88 Very High Very High Very High
Bile 9 98.24 Very High Very High Very High
agonist 30 97.04 Very High Very High Very High
Nicotine 4 83.64 Quite High
Glutamate 4 56.00 Quite High
midbrain 4 43.44 Quite Low
anesthesia 4 28.60 Quite Low
Neurotransmitter 20 26.12 Quite Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 2 99.52 Very High Very High Very High
Endometriosis (extended) 4 98.88 Very High Very High Very High
Repression 4 97.20 Very High Very High Very High
Hepatotoxicity 6 96.24 Very High Very High Very High
Neuroblastoma 36 93.48 High High
Toxicity 13 89.36 High High
Stress 4 76.68 Quite High
Necrosis 6 74.24 Quite High
Cancer 68 73.88 Quite High
Drug Induced Neurotoxicity 28 73.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
include Cyp27a1 which is downregulated by PPAR?
Gene_expression (include) of Cyp
1) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0 Pain Relevance 0.28
The results are consistent with the hypothesis that CYP1A1 produces NAPQI preferentially because of closer proximity of the heme iron to the amide nitrogen, whereas CYP2B1 produces 3-OH-APAP preferentially because of closer proximity of the heme iron to the phenolic oxygen in this isoform.
Gene_expression (produces) of CYP1A1
2) Confidence 0.64 Published 1994 Journal J. Med. Chem. Section Abstract Doc Link 8145237 Disease Relevance 0 Pain Relevance 0.07
The simultaneous treatment of the cocultures with phenobarbital and LPS (10 ng/ml) or 3-methylcholanthrene and LPS (10 ng/ml) resulted in a strong down-regulation (85%) of the phenobarbital-induced cytochrome P450 (CYP) isoform CYP2B1 in the hepatocytes whereas the 3-methylcholanthrene-induced isoform CYP1A1 was only weakly affected (15%).
Gene_expression (affected) of CYP1A1 in hepatocytes
3) Confidence 0.56 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10096772 Disease Relevance 0.22 Pain Relevance 0.08
Roles of cytochromes P-450IA1 and IIIA2.
Gene_expression (Roles) of P-450IA1
4) Confidence 0.51 Published 1991 Journal Drug Metab. Dispos. Section Title Doc Link 1676635 Disease Relevance 0.10 Pain Relevance 0.29
BACKGROUND: The aim of the study was to test whether the COMT, CYP1A1 and CYP17 genes influence the risk of developing adenomyosis and endometriosis.
Gene_expression (influence) of CYP1A1 associated with endometriosis and dismenorea
5) Confidence 0.33 Published 2006 Journal Hum. Reprod. Section Abstract Doc Link 16527884 Disease Relevance 0.35 Pain Relevance 0.26
This is based on the finding that the increase of CYP1A1 mRNA expression caused by over-expression of exogenous AhR was clearly suppressed by repression of the AhR with siRNA.
Gene_expression (expression) of CYP1A1 mRNA associated with repression
6) Confidence 0.28 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.43 Pain Relevance 0
AhR, CYP1A1 and cdc42 mRNA expression were quantified in AhR by real-time PCR.
Gene_expression (expression) of CYP1A1
7) Confidence 0.28 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
The most frequent genotypes in the sample were CYP1A1 wt/wt, with GSTM1 null deletion and at least one functional allele of GSTT1, and CYP1A1 wt/wt, with at least one functional allele of GSTM1 and GSTT1 (33% and 31%, respectively).
Gene_expression (wt/wt) of CYP1A1
8) Confidence 0.28 Published 2001 Journal Fertil. Steril. Section Body Doc Link 11730751 Disease Relevance 0.06 Pain Relevance 0
The expression levels of AhR and CYP1A1 mRNAs were normalized to those of cyclophilin mRNA.
Gene_expression (expression) of CYP1A1
9) Confidence 0.25 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
As stated above, the expression of both AhR and CYP1A1 were high in N2a-R?
Gene_expression (expression) of CYP1A1
10) Confidence 0.22 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
Andrographolide significantly induced the expression of CYP1A1 and CYP1A2 mRNAs in a concentration-dependent manner, and synergistically induced CYP1A1 expression with the typical CYP1A inducers [95,96].
Gene_expression (expression) of CYP1A1
11) Confidence 0.22 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.36 Pain Relevance 0.13
CYP1A1, CYP2A6 and CYP2B6 are expressed both in liver and in kidney resulting to an LKM staining pattern, while CYP1A2 is not expressed in the kidney leading to the LM staining.
Gene_expression (expressed) of CYP1A1 in kidney
12) Confidence 0.20 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 0.32 Pain Relevance 0
Andrographolide significantly induced the expression of CYP1A1 and CYP1A2 mRNAs in a concentration-dependent manner, and synergistically induced CYP1A1 expression with the typical CYP1A inducers [95,96].
Gene_expression (expression) of CYP1A1
13) Confidence 0.19 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.38 Pain Relevance 0.14

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