INT13675

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Context Info
Confidence 0.39
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 23
Total Number 25
Disease Relevance 4.52
Pain Relevance 7.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2c22)
Anatomy Link Frequency
liver 4
heart 2
plasma 1
neurons 1
brain 1
Cyp2c22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 17 99.62 Very High Very High Very High
tolerance 44 99.46 Very High Very High Very High
Paracetamol 554 99.36 Very High Very High Very High
depression 1 99.10 Very High Very High Very High
Pain 13 99.06 Very High Very High Very High
Arthritis 14 98.82 Very High Very High Very High
IPN 2 98.72 Very High Very High Very High
Potency 2 96.72 Very High Very High Very High
Angina 4 95.12 Very High Very High Very High
Glutamate 4 94.56 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 11 99.62 Very High Very High Very High
Depression 1 99.10 Very High Very High Very High
Stress 33 99.02 Very High Very High Very High
Arthritis 22 98.82 Very High Very High Very High
Inflammatory Pain 2 98.72 Very High Very High Very High
Hepatotoxicity 18 98.28 Very High Very High Very High
Aging 8 98.12 Very High Very High Very High
Injury 6 97.00 Very High Very High Very High
Cancer 2 95.44 Very High Very High Very High
Cv General 3 Under Development 4 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To elucidate the P-450 forms involved in these divergent effects, rat liver microsomes, prepared after pretreatment with various inducers, were used to examine the effect of caffeine on N-acetyl-p-benzoquinone imine (NAPQI) formation.
Gene_expression (elucidate) of P-450 in liver
1) Confidence 0.39 Published 1991 Journal Drug Metab. Dispos. Section Abstract Doc Link 1676635 Disease Relevance 0.10 Pain Relevance 0.27
After the pretreatment with PB, TI produced higher microsomal cytochrome P-450 contents than in the control group.
Gene_expression (produced) of P-450
2) Confidence 0.36 Published 1994 Journal Masui Section Abstract Doc Link 7815706 Disease Relevance 0 Pain Relevance 0.39
In addition, uridine 5'-diphosphate-glucuronosyltransferase activity toward bilirubin and p-nitrophenol, as well as levels of cytochrome P-450 and beta-glucuronidase were determined in these microsomal preparations.
Gene_expression (levels) of P-450
3) Confidence 0.20 Published 1999 Journal Drug Metab. Dispos. Section Abstract Doc Link 9884306 Disease Relevance 0.57 Pain Relevance 0.33
Adjuvant-induced arthritis resulted in a significant reduction in hepatic cytochrome P-450 levels and in p-nitrophenol glucuronidation (5.65 +/- 0.40 versus 2.58 +/- 0.27 micromol.min/mg protein in control and arthritic rats, respectively, mean +/- S.E.M.).
Gene_expression (levels) of P-450 associated with arthritis
4) Confidence 0.20 Published 1999 Journal Drug Metab. Dispos. Section Abstract Doc Link 9884306 Disease Relevance 0.64 Pain Relevance 0.32
The metabolic activation of paracetamol (acetaminophen) to reactive intermediate(s) which bind covalently to proteins was studied in reconstituted systems, employing highly purified preparations of cytochromes P-450 and P-448 isolated from the liver of rats pretreated with phenobarbitone and beta-naphthoflavone respectively.
Gene_expression (preparations) of cytochromes P-450 in liver associated with paracetamol
5) Confidence 0.17 Published 1983 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6867468 Disease Relevance 0 Pain Relevance 0.42
This P-450 isoenzyme is very abundant in the liver [36] and is also expressed in the brain [10], although at much lower levels, where it seems to play an important role in metabolizing some compounds like AAP and ethanol.
Gene_expression (expressed) of P-450 in brain associated with paracetamol
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.48 Pain Relevance 0.98
PURPOSE: This study was designed to examine the effect of Freund's complete adjuvant (FCA)-induced inflammation on liver P450 expression and activities in the first 7 days that followed a single FCA injection in the rat hindpaw.
Gene_expression (expression) of P450 in liver associated with inflammation
7) Confidence 0.06 Published 2005 Journal Pharm. Res. Section Abstract Doc Link 15771231 Disease Relevance 0.17 Pain Relevance 0.12
Cytochrome P450 2E1 isoform (CYP2E1) activity was expressed as nmoles of p-nitrophenol transformed/mg of protein/h.
Gene_expression (expressed) of P450
8) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.08 Pain Relevance 0.30
Our experiments show that cortical neurons not only express the 2E1 isoform of cytochrome P-450, but also that AAP enhances its levels and activity after 18 h of treatment.
Gene_expression (express) of P-450 in neurons associated with paracetamol
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.49 Pain Relevance 1.01
Selective downregulation of hepatic cytochrome P450 expression and activity in a rat model of inflammatory pain.
Gene_expression (expression) of P450 associated with inflammation and ipn
10) Confidence 0.06 Published 2005 Journal Pharm. Res. Section Title Doc Link 15771231 Disease Relevance 0.19 Pain Relevance 0.49
Vitamin E deficiency accelerates nitrate tolerance via a decrease in cardiac P450 expression and increased oxidative stress.
Gene_expression (expression) of P450 associated with stress and tolerance
11) Confidence 0.05 Published 2006 Journal Free Radic. Biol. Med. Section Title Doc Link 16520233 Disease Relevance 0.26 Pain Relevance 0.38
In conclusion, because continuous NTG infusion causes vitamin E depletion as well as nitrate tolerance, vitamin E deficiency may further accelerate nitrate tolerance via an increase in oxidative stress, the reduced bioconversion because of decreased P450 expression, and impairment of the NO/cGMP pathway in tolerant heart tissues.
Gene_expression (expression) of P450 in heart associated with stress and tolerance
12) Confidence 0.05 Published 2006 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16520233 Disease Relevance 0.17 Pain Relevance 0.24
Cardiac P450 expression (CYP1A2) assessed by immunoblotting, markedly decreased 48 h after NTG administration in control rats.
Gene_expression (expression) of P450
13) Confidence 0.05 Published 2006 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16520233 Disease Relevance 0.23 Pain Relevance 0.41
Conversely, limitation of sulfur-containing amino acids could result in depression of protein synthesis and hepatic cytochrome P450 levels, and hence in decreased reactive metabolite formation and decreased liver injury.
Gene_expression (levels) of P450 in liver associated with depression and injury
14) Confidence 0.04 Published 1989 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2815088 Disease Relevance 0.37 Pain Relevance 0.42
In contrast, vitamin E-deficient hearts had lower P450 expression and higher free radical generation than control hearts.
Gene_expression (expression) of P450 in hearts
15) Confidence 0.03 Published 2006 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16520233 Disease Relevance 0.20 Pain Relevance 0.38
This compound also inactivated the EFC activity in microsomes from human lymphoblastoid cells expressing human P450 2B6.
Gene_expression (expressing) of P450
16) Confidence 0.03 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9351899 Disease Relevance 0 Pain Relevance 0.16
During puberty, young adulthood, and senescence, changes in the hormonal profiles appear to be responsible for alterations in age-associated expression levels of selective P450 isoforms.
Gene_expression (expression) of P450 associated with aging
17) Confidence 0.03 Published 2002 Journal Drug Metab. Dispos. Section Abstract Doc Link 11792682 Disease Relevance 0.10 Pain Relevance 0
These changes in GRF-induced, sexually dimorphic secretory growth hormone profiles and the accompanying decline in P450 expression levels may anticipate similar, but more profound, changes to occur during senescence.
Gene_expression (expression) of P450 associated with aging
18) Confidence 0.03 Published 2002 Journal Drug Metab. Dispos. Section Abstract Doc Link 11792682 Disease Relevance 0.10 Pain Relevance 0.23
Cytochrome P450IIE was detected immunologically and enzymatically, using two activities associated with cytochrome P450IIE, p-nitrophenol hydroxylation, and acetaminophen activation to a metabolite that binds to glutathione.
Gene_expression (detected) of P450IIE associated with paracetamol
19) Confidence 0.02 Published 1991 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 1989519 Disease Relevance 0.09 Pain Relevance 0.09
Middle-age alterations in the sexually dimorphic plasma growth hormone profiles: involvement of growth hormone-releasing factor and effects on cytochrome p450 expression.
Gene_expression (expression) of p450 in plasma
20) Confidence 0.02 Published 2002 Journal Drug Metab. Dispos. Section Title Doc Link 11792682 Disease Relevance 0.09 Pain Relevance 0.06

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