INT136751

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.65
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SCARB1) small molecule metabolic process (SCARB1) cell adhesion (SCARB1)
plasma membrane (SCARB1) lipid metabolic process (SCARB1) cytoplasm (SCARB1)
Anatomy Link Frequency
plaques 1
SCARB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 99.98 Very High Very High Very High
aspirin 9 99.96 Very High Very High Very High
cOX1 1 91.20 High High
cINOD 1 86.16 High High
cannabis 16 81.76 Quite High
cocaine 28 81.36 Quite High
drug abuse 57 41.44 Quite Low
opiate 1 36.92 Quite Low
Angina 12 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 1 99.98 Very High Very High Very High
Disorder Of Lipid Metabolism 60 99.76 Very High Very High Very High
Atherosclerotic Plaque 76 97.92 Very High Very High Very High
Atherosclerosis 117 97.84 Very High Very High Very High
Sprains And Strains 1 90.20 High High
Increased Venous Pressure Under Development 1 81.96 Quite High
Targeted Disruption 7 77.68 Quite High
Hypoxia 42 66.08 Quite High
Drug Dependence 58 41.44 Quite Low
Urological Neuroanatomy 1 30.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, using 5 mmol/l of aspirin, SR-BI expression and function were significantly decreased.
Negative_regulation (decreased) of SR-BI associated with aspirin
1) Confidence 0.43 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816107 Disease Relevance 0.42 Pain Relevance 0.44
Bone marrow transplantation studies have shown that SR-BI disruption in macrophages augment the development of advanced atherosclerotic plaques [10,27].
Negative_regulation (disruption) of SR-BI in plaques associated with atherosclerotic plaque
2) Confidence 0.42 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.64 Pain Relevance 0
This effect could be related to the scavenger receptor function of SR-BI by enhancing uptake of oxidized LDL or VLDL [28].
Negative_regulation (function) of SR-BI
3) Confidence 0.42 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.96 Pain Relevance 0
Digestion with Nco I resulted in a 53-bp decrease in fragment size of both SR-BI (423 bp) and SR-BII (294 bp) as predicted from the mRNA sequence.
Negative_regulation (decrease) of SR-BI
4) Confidence 0.42 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.35 Pain Relevance 0
Expression of transcripts encoding the first specific step in the cholesterol biosynthetic pathway (FDFT1), the high-density lipoprotein (HDL) receptor (SCARB1) and an inhibitor of cholesterol biosynthesis (PRKAB1) were increased.
Negative_regulation (inhibitor) of SCARB1 associated with disorder of lipid metabolism
5) Confidence 0.28 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.18 Pain Relevance 0.08
Tests using animal models demonstrated that there was a marked pain reduction following the injection of ClaE compared with clarithromycin solution.
Negative_regulation (reduction) of ClaE associated with pain
6) Confidence 0.03 Published 2008 Journal Int J Pharm Section Abstract Doc Link 17640833 Disease Relevance 0.10 Pain Relevance 0.17

General Comments

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