INT136752

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 17
Disease Relevance 10.63
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SCARB1) small molecule metabolic process (SCARB1) cell adhesion (SCARB1)
plasma membrane (SCARB1) lipid metabolic process (SCARB1) cytoplasm (SCARB1)
Anatomy Link Frequency
macrophages 22
liver 2
SCARB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 36 99.74 Very High Very High Very High
cOX1 4 98.12 Very High Very High Very High
cINOD 4 93.16 High High
Bile 39 57.80 Quite High
Angina 52 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerotic Plaque 329 100.00 Very High Very High Very High
Hypoxia 182 100.00 Very High Very High Very High
Atherosclerosis 507 99.64 Very High Very High Very High
Disorder Of Lipid Metabolism 238 99.00 Very High Very High Very High
Targeted Disruption 30 98.84 Very High Very High Very High
Sprains And Strains 4 97.20 Very High Very High Very High
Increased Venous Pressure Under Development 4 88.96 High High
Cv General 3 Under Development 52 5.00 Very Low Very Low Very Low
Myocardial Infarction 26 5.00 Very Low Very Low Very Low
Hypertension 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In in vivo studies low-dose aspirin treatment (6 mg/kg.day) induced SR-BI expression in wild-type and PPAR-alpha knockout mice, respectively, whereas the opposite effect was observed upon high-dose aspirin treatment (60 mg/kg.day) in these animals.
Positive_regulation (induced) of Gene_expression (expression) of SR-BI associated with targeted disruption and aspirin
1) Confidence 0.69 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816107 Disease Relevance 0.40 Pain Relevance 0.46
However, less differentiated macrophages (3 days differentiation) responded to 16 h of oxLDL treatment with increased SR-BI expression [30].
Positive_regulation (increased) of Gene_expression (expression) of SR-BI in macrophages
2) Confidence 0.68 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.52 Pain Relevance 0
Hirano et al reported an increased expression of SR-BI during macrophage differentiation and that oxLDL induced SR-BI mRNA and protein expression after 24 h of treatment [29].
Positive_regulation (increased) of Gene_expression (expression) of SR-BI in macrophage
3) Confidence 0.68 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.70 Pain Relevance 0
In in vivo studies low-dose aspirin treatment (6 mg/kg.day) induced SR-BI expression in wild-type and PPAR-alpha knockout mice, respectively, whereas the opposite effect was observed upon high-dose aspirin treatment (60 mg/kg.day) in these animals.
Positive_regulation (induced) of Gene_expression (expression) of SR-BI associated with targeted disruption and aspirin
4) Confidence 0.50 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816107 Disease Relevance 0.40 Pain Relevance 0.46
Hirano et al reported an increased expression of SR-BI during macrophage differentiation and that oxLDL induced SR-BI mRNA and protein expression after 24 h of treatment [29].
Positive_regulation (induced) of Gene_expression (expression) of SR-BI in macrophage
5) Confidence 0.49 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.67 Pain Relevance 0
Expression of SR-BI in macrophages derived from subjects with atherosclerosis
Positive_regulation (macrophages) of Gene_expression (Expression) of SR-BI in macrophages associated with atherosclerosis
6) Confidence 0.49 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.91 Pain Relevance 0
Macrophage SR-BI expression levels were not correlated to serum HDL cholesterol levels in the macrophage INTERGENE subjects (data not shown).


Positive_regulation (Macrophage) of Gene_expression (expression) of SR-BI in Macrophage associated with disorder of lipid metabolism
7) Confidence 0.49 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.66 Pain Relevance 0
This indicates that the differentiation status of the macrophages and the time of oxLDL treatment influences SR-BI expression.
Positive_regulation (influences) of Gene_expression (expression) of SR-BI in macrophages
8) Confidence 0.49 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.50 Pain Relevance 0
Differences in chemical properties of mmLDL compared to oxLDL can affect macrophage SR-BI expression.
Positive_regulation (macrophage) of Gene_expression (expression) of SR-BI in macrophage
9) Confidence 0.49 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.44 Pain Relevance 0
However, the analysis confirms the previous findings that SR-BI expression is increased in response to 24 h mmLDL treatment of macrophages from both the subjects with atherosclerosis and the control subjects (p < 0.05 and p < 0.05, respectively).
Positive_regulation (increased) of Gene_expression (expression) of SR-BI in macrophages associated with atherosclerosis
10) Confidence 0.49 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.72 Pain Relevance 0
Incubation of human macrophages with 0.5 mmol/l aspirin resulted in increased SR-BI protein expression and increased uptake of HDL-associated [3H]cholesteryl oleate without changes of SR-BI mRNA levels.
Positive_regulation (increased) of Gene_expression (expression) of SR-BI in macrophages associated with aspirin and disorder of lipid metabolism
11) Confidence 0.46 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816107 Disease Relevance 0.43 Pain Relevance 0.37
Sodium salicylate exerted similar effects on SR-BI expression, whereas no effects were observed using known COX1/2 inhibitors ibuprofen and naproxen, respectively.
Positive_regulation (exerted) of Gene_expression (expression) of SR-BI associated with cox1
12) Confidence 0.46 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816107 Disease Relevance 0.42 Pain Relevance 0.45
In both groups, SR-BI expression was increased by exposure to mmLDL (p < 0.05).
Positive_regulation (increased) of Gene_expression (expression) of SR-BI
13) Confidence 0.46 Published 2005 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC1215476 Disease Relevance 0.86 Pain Relevance 0
In particular, hepatic overexpression of SR-BI reduces atherosclerotic lesion formation [9], which is attributed to the role of SR-BI in the uptake of HDL-cholesterol in the liver.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SR-BI in liver associated with atherosclerosis and disorder of lipid metabolism
14) Confidence 0.46 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.42 Pain Relevance 0
In contrast, SR-BI expression was increased by exposure to mmLDL (p < 0.05).
Positive_regulation (increased) of Gene_expression (expression) of SR-BI
15) Confidence 0.46 Published 2005 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC1215476 Disease Relevance 0.90 Pain Relevance 0.03
Effect of mmLDL on macrophage SR-BI expression
Positive_regulation (macrophage) of Gene_expression (expression) of SR-BI in macrophage
16) Confidence 0.43 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.73 Pain Relevance 0
Reduced macrophage SR-BI gene expression during hypoxic condition may lead to reduced cholesterol efflux from macrophages in hypoxic zones of the atherosclerotic plaque and may increase foam cell formation in these areas.
Spec (may) Positive_regulation (increase) of Gene_expression (expression) of SR-BI gene in macrophage associated with atherosclerotic plaque and hypoxia
17) Confidence 0.43 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.93 Pain Relevance 0

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