INT136753

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2006
Negated 0
Speculated 3
Reported most in Body
Documents 2
Total Number 13
Disease Relevance 7.79
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SCARB1) small molecule metabolic process (SCARB1) cell adhesion (SCARB1)
plasma membrane (SCARB1) lipid metabolic process (SCARB1) cytoplasm (SCARB1)
Anatomy Link Frequency
macrophages 16
plaques 2
SCARB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 18 100.00 Very High Very High Very High
cINOD 2 100.00 Very High Very High Very High
cOX1 2 98.12 Very High Very High Very High
Bile 33 43.68 Quite Low
Angina 44 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 154 100.00 Very High Very High Very High
Atherosclerotic Plaque 277 99.80 Very High Very High Very High
Atherosclerosis 429 99.08 Very High Very High Very High
Increased Venous Pressure Under Development 2 97.28 Very High Very High Very High
Sprains And Strains 2 97.04 Very High Very High Very High
Disorder Of Lipid Metabolism 200 96.48 Very High Very High Very High
Targeted Disruption 24 82.72 Quite High
Cv General 3 Under Development 44 5.00 Very Low Very Low Very Low
Myocardial Infarction 22 5.00 Very Low Very Low Very Low
Hypertension 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we show for the first time that SR-BI gene expression is down regulated by hypoxia.
Regulation (regulated) of Gene_expression (expression) of SR-BI gene associated with hypoxia
1) Confidence 0.60 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.98 Pain Relevance 0
Differences in chemical properties of mmLDL compared to oxLDL can affect macrophage SR-BI expression.
Regulation (affect) of Gene_expression (expression) of SR-BI in macrophage
2) Confidence 0.60 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.44 Pain Relevance 0
Analysis of SR-BI isoforms in macrophages and atherosclerotic plaques
Regulation (macrophages) of Gene_expression (isoforms) of SR-BI in plaques associated with atherosclerotic plaque
3) Confidence 0.44 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.63 Pain Relevance 0
The expression of SR-BI was significantly up regulated in macrophages after mmLDL treatment compared to control macrophages (p < 0.05, Figure 1) as determined by real-time RT-PCR analysis.


Regulation (regulated) of Gene_expression (expression) of SR-BI in macrophages
4) Confidence 0.44 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.86 Pain Relevance 0
Sodium salicylate exerted similar effects on SR-BI expression, whereas no effects were observed using known COX1/2 inhibitors ibuprofen and naproxen, respectively.
Regulation (effects) of Gene_expression (expression) of SR-BI associated with cox1
5) Confidence 0.27 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816107 Disease Relevance 0.41 Pain Relevance 0.45
In this study we investigated the influence of aspirin and other NSAIDs on SR-BI expression and function in cultured human macrophages as well as in different mouse strains.
Spec (investigated) Regulation (influence) of Gene_expression (expression) of SR-BI in macrophages associated with aspirin, cinod and sprains and strains
6) Confidence 0.27 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816107 Disease Relevance 0.37 Pain Relevance 0.33
This indicates that altered SR-BI expression is not a common feature of atherosclerosis.
Regulation (altered) of Gene_expression (expression) of SR-BI associated with atherosclerosis
7) Confidence 0.27 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.65 Pain Relevance 0
This indicates that the differentiation status of the macrophages and the time of oxLDL treatment influences SR-BI expression.
Regulation (influences) of Gene_expression (expression) of SR-BI in macrophages
8) Confidence 0.27 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.50 Pain Relevance 0
Genetically modified mice models have also been used to investigate the role of macrophage SR-BI expression in the development of atherosclerosis.
Spec (investigate) Regulation (role) of Spec (investigate) Gene_expression (expression) of SR-BI in macrophage associated with atherosclerosis
9) Confidence 0.27 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.53 Pain Relevance 0
The results of this experiment indicate that altered expression of SR-BI in macrophages is not a common component in the development on atherosclerosis in the Swedish population.
Regulation (altered) of Gene_expression (expression) of SR-BI in macrophages associated with atherosclerosis
10) Confidence 0.27 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.55 Pain Relevance 0
We therefore investigated if macrophage SR-BI expression is regulated by hypoxia in vitro.
Spec (investigated) Regulation (regulated) of Gene_expression (expression) of SR-BI in macrophage associated with hypoxia
11) Confidence 0.27 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.70 Pain Relevance 0
This indicates that altered SR-BI expression is not a common cause of atherosclerosis.
Regulation (altered) of Gene_expression (expression) of SR-BI associated with atherosclerosis
12) Confidence 0.27 Published 2005 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC1215476 Disease Relevance 0.54 Pain Relevance 0
Effect of hypoxia on macrophage SR-BI expression
Regulation (Effect) of Gene_expression (expression) of SR-BI in macrophage associated with hypoxia
13) Confidence 0.23 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.62 Pain Relevance 0

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