INT136754

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 64
Total Number 68
Disease Relevance 43.28
Pain Relevance 4.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SCARB1) small molecule metabolic process (SCARB1) cell adhesion (SCARB1)
plasma membrane (SCARB1) lipid metabolic process (SCARB1) cytoplasm (SCARB1)
Anatomy Link Frequency
macrophages 37
plaques 9
liver 2
plasma 1
brains 1
SCARB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 90 99.96 Very High Very High Very High
cINOD 10 99.92 Very High Very High Very High
cOX1 10 98.12 Very High Very High Very High
Angina 216 89.60 High High
cannabis 32 87.88 High High
cocaine 56 87.48 High High
Bile 162 85.12 High High
drug abuse 114 58.08 Quite High
opiate 2 43.04 Quite Low
cytokine 11 26.96 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 992 100.00 Very High Very High Very High
Atherosclerosis 2106 99.84 Very High Very High Very High
Hypoxia 756 99.70 Very High Very High Very High
Atherosclerotic Plaque 1360 99.60 Very High Very High Very High
Targeted Disruption 134 98.84 Very High Very High Very High
Hepatitis C Virus Infection 189 98.72 Very High Very High Very High
Congenital Anomalies 55 98.28 Very High Very High Very High
Sprains And Strains 14 97.04 Very High Very High Very High
Increased Venous Pressure Under Development 10 96.92 Very High Very High Very High
Myocardial Infarction 108 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In in vivo studies low-dose aspirin treatment (6 mg/kg.day) induced SR-BI expression in wild-type and PPAR-alpha knockout mice, respectively, whereas the opposite effect was observed upon high-dose aspirin treatment (60 mg/kg.day) in these animals.
Gene_expression (expression) of SR-BI associated with targeted disruption and aspirin
1) Confidence 0.77 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816107 Disease Relevance 0.40 Pain Relevance 0.46
In this study we show that SR-BI expression in macrophages is increased in response to 24 h of mmLDL treatment.
Gene_expression (expression) of SR-BI in macrophages
2) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.49 Pain Relevance 0
The results of this experiment indicate that altered expression of SR-BI in macrophages is not a common component in the development on atherosclerosis in the Swedish population.
Gene_expression (expression) of SR-BI in macrophages associated with atherosclerosis
3) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.54 Pain Relevance 0
However, the analysis confirms the previous findings that SR-BI expression is increased in response to 24 h mmLDL treatment of macrophages from both the subjects with atherosclerosis and the control subjects (p < 0.05 and p < 0.05, respectively).
Gene_expression (expression) of SR-BI in macrophages associated with atherosclerosis
4) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.72 Pain Relevance 0
Previous studies have shown disparate effect of highly oxidized LDL (oxLDL) on SR-BI expression in human monocyte-derived macrophages.
Gene_expression (expression) of SR-BI in macrophages
5) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.78 Pain Relevance 0
Macrophage SR-BI expression levels were not correlated to serum HDL cholesterol levels in the macrophage INTERGENE subjects (data not shown).


Gene_expression (expression) of SR-BI in Macrophage associated with disorder of lipid metabolism
6) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.66 Pain Relevance 0
In addition, we identified SR-BIII as a novel SR-BI isoform expressed in human macrophages and in human atherosclerotic plaques.


Gene_expression (expressed) of SR-BI isoform in macrophages associated with atherosclerotic plaque
7) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.59 Pain Relevance 0
In this study we show for the first time that SR-BI gene expression is down regulated by hypoxia.
Gene_expression (expression) of SR-BI gene associated with hypoxia
8) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.97 Pain Relevance 0
Differences in chemical properties of mmLDL compared to oxLDL can affect macrophage SR-BI expression.
Gene_expression (expression) of SR-BI in macrophage
9) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.44 Pain Relevance 0
However, a recent study by Van Eck et al shows that the development of early atherosclerotic plaque (fatty streaks) is reduced in macrophages lacking SR-BI expression [28].
Gene_expression (expression) of SR-BI in plaque associated with atherosclerotic plaque
10) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.84 Pain Relevance 0
SR-BI gene expression in macrophages and mmLDL-treated macrophages from 15 atherosclerotic subjects and 15 controls (the macrophage INTERGENE subjects) were analyzed by real-time RT-PCR (Figure 2).
Gene_expression (expression) of SR-BI gene in macrophage associated with atherosclerosis
11) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.81 Pain Relevance 0
The expression of SR-BI was significantly up regulated in macrophages after mmLDL treatment compared to control macrophages (p < 0.05, Figure 1) as determined by real-time RT-PCR analysis.


Gene_expression (expression) of SR-BI in macrophages
12) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.85 Pain Relevance 0
Expression of SR-BI in macrophages derived from subjects with atherosclerosis
Gene_expression (Expression) of SR-BI in macrophages associated with atherosclerosis
13) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.91 Pain Relevance 0
We have previously identified a PTS1 motif in the C-terminus of SR-BI [8,24], which is not present in SR-BII and SR-BIII.
Neg (not) Gene_expression (present) of SR-BI
14) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.72 Pain Relevance 0.04
Real-time PCR analysis of SR-BI gene expression
Gene_expression (expression) of SR-BI gene
15) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.09 Pain Relevance 0
As different isoforms of SR-BI may modulate receptor function [23], the expression of SR-BI isoforms was investigated in human macrophages by RT-PCR using primers designed to detect both SR-BI and SR-BII transcripts.
Spec (investigated) Gene_expression (expression) of SR-BI in macrophages
16) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.60 Pain Relevance 0
This indicates that the differentiation status of the macrophages and the time of oxLDL treatment influences SR-BI expression.
Gene_expression (expression) of SR-BI in macrophages
17) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.49 Pain Relevance 0
Hirano et al reported an increased expression of SR-BI during macrophage differentiation and that oxLDL induced SR-BI mRNA and protein expression after 24 h of treatment [29].
Gene_expression (expression) of SR-BI in macrophage
18) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.69 Pain Relevance 0
As SR-BI gene expression in macrophages may modulate the development of atherosclerosis we investigated if macrophages derived from subjects with atherosclerosis displayed an altered expression pattern compared to macrophages derived from matched healthy controls.
Gene_expression (expression) of SR-BI gene in macrophages associated with atherosclerosis
19) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.41 Pain Relevance 0
As SR-BI expression in macrophages may modulate the development of atherosclerosis we investigated if macrophages derived from subjects with atherosclerosis displayed an altered expression pattern compared to macrophages derived from matched healthy controls.
Gene_expression (expression) of SR-BI in macrophages associated with atherosclerosis
20) Confidence 0.76 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.87 Pain Relevance 0

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