INT136755

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 6.61
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SCARB1) small molecule metabolic process (SCARB1) cell adhesion (SCARB1)
plasma membrane (SCARB1) lipid metabolic process (SCARB1) cytoplasm (SCARB1)
Anatomy Link Frequency
macrophages 12
plaque 2
SCARB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 9 99.96 Very High Very High Very High
cOX1 1 91.20 High High
cINOD 1 86.16 High High
Angina 28 78.88 Quite High
Bile 21 61.24 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 98 99.92 Very High Very High Very High
Atherosclerosis 273 99.20 Very High Very High Very High
Atherosclerotic Plaque 176 99.14 Very High Very High Very High
Disorder Of Lipid Metabolism 127 98.52 Very High Very High Very High
Congenital Anomalies 7 93.00 High High
Sprains And Strains 1 90.20 High High
Increased Venous Pressure Under Development 1 81.96 Quite High
Myocardial Infarction 14 80.88 Quite High
Cv General 3 Under Development 28 78.88 Quite High
Targeted Disruption 15 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a recent study by Van Eck et al shows that the development of early atherosclerotic plaque (fatty streaks) is reduced in macrophages lacking SR-BI expression [28].
Negative_regulation (lacking) of Gene_expression (expression) of SR-BI in plaque associated with atherosclerotic plaque
1) Confidence 0.57 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.84 Pain Relevance 0
In contrast, Han et al reported that 10 days differentiated macrophages displayed a decreased SR-BI expression in response to 16 h oxLDL treatment [30].
Negative_regulation (decreased) of Gene_expression (expression) of SR-BI in macrophages
2) Confidence 0.57 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.57 Pain Relevance 0
Reduced macrophage SR-BI gene expression during hypoxic condition may lead to reduced cholesterol efflux from macrophages in hypoxic zones of the atherosclerotic plaque and may increase foam cell formation in these areas.
Negative_regulation (Reduced) of Gene_expression (expression) of SR-BI gene in macrophage associated with atherosclerotic plaque and hypoxia
3) Confidence 0.50 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.98 Pain Relevance 0
In contrast, using 5 mmol/l of aspirin, SR-BI expression and function were significantly decreased.
Negative_regulation (decreased) of Gene_expression (expression) of SR-BI associated with aspirin
4) Confidence 0.43 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816107 Disease Relevance 0.42 Pain Relevance 0.44
Therefore, decreased macrophage expression of human SR-BI may be a mechanism that promotes the development of atherosclerosis.
Negative_regulation (decreased) of Gene_expression (expression) of SR-BI in macrophage associated with atherosclerosis
5) Confidence 0.42 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 1.19 Pain Relevance 0.16
The expression of macrophage SR-BI was decreased from 1.26 ± 0.17 arbitrary units to 0.73 ± 0.10 arbitrary units (mean ± SEM; p < 0.005) after hypoxia exposure as determined by real-time RT-PCR analysis.


Negative_regulation (decreased) of Gene_expression (expression) of SR-BI in macrophage associated with hypoxia
6) Confidence 0.42 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.71 Pain Relevance 0
SR-BI expression was decreased in macrophages after hypoxia (p < 0.005).
Negative_regulation (decreased) of Gene_expression (expression) of SR-BI in macrophages associated with hypoxia
7) Confidence 0.42 Published 2005 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC1215476 Disease Relevance 0.97 Pain Relevance 0.03
Expression of SR-BI in macrophages derived from subjects with atherosclerosis
Negative_regulation (derived) of Gene_expression (Expression) of SR-BI in macrophages associated with atherosclerosis
8) Confidence 0.42 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.92 Pain Relevance 0

General Comments

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