INT136757

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.96
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SCARB1) small molecule metabolic process (SCARB1) cell adhesion (SCARB1)
plasma membrane (SCARB1) lipid metabolic process (SCARB1) cytoplasm (SCARB1)
Anatomy Link Frequency
macrophages 2
SCARB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 9 97.64 Very High Very High Very High
cINOD 1 88.96 High High
Bile 6 88.92 High High
cOX1 1 82.64 Quite High
drug abuse 57 58.08 Quite High
cocaine 28 50.00 Quite Low
cannabis 16 50.00 Quite Low
Angina 8 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 42 99.14 Very High Very High Very High
Atherosclerotic Plaque 51 98.96 Very High Very High Very High
Sprains And Strains 1 93.00 High High
Atherosclerosis 78 92.56 High High
Increased Venous Pressure Under Development 1 84.76 Quite High
Hypoxia 28 72.72 Quite High
Targeted Disruption 5 69.12 Quite High
Drug Dependence 58 58.08 Quite High
Phencyclidine Abuse 4 25.76 Quite Low
Cardiovascular Disease 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation of human macrophages with 0.5 mmol/l aspirin resulted in increased SR-BI protein expression and increased uptake of HDL-associated [3H]cholesteryl oleate without changes of SR-BI mRNA levels.
Neg (without) Regulation (changes) of SR-BI mRNA in macrophages associated with aspirin and disorder of lipid metabolism
1) Confidence 0.27 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816107 Disease Relevance 0.43 Pain Relevance 0.41
We conclude that SR-BI is regulated by proatherogenic stimuli in humans.
Regulation (regulated) of SR-BI
2) Confidence 0.27 Published 2005 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC1215476 Disease Relevance 0.60 Pain Relevance 0
Regulation and splicing of scavenger receptor class B type I in human macrophages and atherosclerotic plaques

Background

Regulation (Regulation) of scavenger receptor class B type I in macrophages associated with atherosclerotic plaque
3) Confidence 0.27 Published 2005 Journal BMC Cardiovasc Disord Section Title Doc Link PMC1215476 Disease Relevance 0.78 Pain Relevance 0.04
Most transcripts regulating cholesterol biosynthesis (FDFT1, PRKAB1) and trafficking (SCARB1, APOL2) were increased, but transcription of the secreted apolipoprotein APOL1 and a peroxisomal protein (ECHDC1) involved in beta-oxidation of cholesterol were decreased.
Regulation (regulating) of SCARB1 associated with disorder of lipid metabolism
4) Confidence 0.17 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

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