INT136758

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.52
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, PTGES) isomerase activity (PTGES) extracellular space (TNF)
extracellular region (TNF) plasma membrane (TNF) intracellular (TNF)
Anatomy Link Frequency
neurons 2
TNF (Homo sapiens)
PTGES (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 4 99.60 Very High Very High Very High
COX-2 inhibitor 2 96.92 Very High Very High Very High
Pain 2 95.12 Very High Very High Very High
Inflammation 2 94.88 High High
cOX1 8 75.00 Quite High
Disease Link Frequency Relevance Heat
Fever 2 95.56 Very High Very High Very High
Pain 2 95.12 Very High Very High Very High
INFLAMMATION 2 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SC-560 treatment neither altered TNFalpha-induced COX-2 or mPGES-1 expression nor did the addition of the calcium ionophore A23187 or arachidonic acid reverse the inhibition by SC-560.
TNFalpha Neg (nor) Positive_regulation (induced) of Gene_expression (expression) of mPGES-1
1) Confidence 0.05 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816110 Disease Relevance 0.23 Pain Relevance 0.28
TNFalpha induced COX-2 and mPGES-1 expression in neurons, followed by formation of PGE2, which was blocked by a selective COX-2 inhibitor.
TNFalpha Positive_regulation (induced) of Gene_expression (expression) of mPGES-1 in neurons associated with cox-2 inhibitor
2) Confidence 0.05 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816110 Disease Relevance 0.29 Pain Relevance 0.28

General Comments

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