INT136772

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 0.61
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv6) transmembrane transport (Trpv6)
Anatomy Link Frequency
uterine 2
placenta 2
Trpv6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 48 99.68 Very High Very High Very High
member 8 13 86.32 High High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 6 99.86 Very High Very High Very High
Targeted Disruption 24 94.56 High High
Osteoporosis 2 66.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Uterine TRPV6 mRNA levels increased at mid and late pregnancy, and were strongly induced at mid-pregnancy in the labyrinth and spongy zones of the placenta, and in the fetal membrane [12].
Positive_regulation (induced) of TRPV6 mRNA in placenta
1) Confidence 0.70 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0.12 Pain Relevance 0.04
Dietary calcium can also induce duodenal and renal TRPV6 mRNA expression [5,14], and estrogen therapy in menopausal women induces duodenal TRPV6 mRNA, suggesting that this hormone independently modulates TRPV6 expression [15].
Positive_regulation (induces) of TRPV6 mRNA associated with endometriosis (extended)
2) Confidence 0.70 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0.25 Pain Relevance 0.06
TRPV6, TRPV5, and calbindin-D9k mRNA levels were also upregulated, resulting in prevention of the reduction in lumbar BMD.
Positive_regulation (upregulated) of TRPV6
3) Confidence 0.68 Published 2006 Journal J. Bone Miner. Metab. Section Abstract Doc Link 16816923 Disease Relevance 0.12 Pain Relevance 0.09
Uterine TRPV6 mRNA levels increased at mid and late pregnancy, and were strongly induced at mid-pregnancy in the labyrinth and spongy zones of the placenta, and in the fetal membrane [12].
Positive_regulation (induced) of TRPV6 mRNA in placenta
4) Confidence 0.50 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0.12 Pain Relevance 0.04
Effects of sex steroid receptor antagonists on uterine and placental TRPV6 mRNA in a rat and mouse model
Positive_regulation (placental) of TRPV6 mRNA in uterine associated with antagonist
5) Confidence 0.50 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0.05
TRPV6 mRNA was moderately expressed at P0.5, decreased through P4.5, and then suddenly increased to the highest level at P5.5 (Figure 1).
Positive_regulation (increased) of TRPV6 mRNA
6) Confidence 0.47 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0
Uterine TRPV6 peaked at pregnancy day (P) 0.5, P5.5 and, P13.5 and was detected in uterine epithelium and glands of rats, while placental TRPV6 mRNA levels increased in mid-gestation.
Positive_regulation (increased) of TRPV6 mRNA in uterine
7) Confidence 0.47 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0.09

General Comments

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