INT136785

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Context Info
Confidence 0.82
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Eif4e) protein complex (Eif4e) cytoplasm (Eif4e)
Anatomy Link Frequency
dentate gyrus 1
Eif4e (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 34 99.20 Very High Very High Very High
Hippocampus 18 98.36 Very High Very High Very High
fluoxetine 38 96.16 Very High Very High Very High
antidepressant 25 87.92 High High
monoamine 1 6.44 Low Low
depression 3 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 3 38.84 Quite Low
Aids-related Complex 14 14.96 Low Low
Stress 4 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Amnesia 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Affective Disorder 1 5.00 Very Low Very Low Very Low
Convulsion 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By contrast, phosphorylation of eIF4E (Ser209) was observed specifically in the dentate gyrus.
Phosphorylation (phosphorylation) of eIF4E in dentate gyrus
1) Confidence 0.82 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16817885 Disease Relevance 0 Pain Relevance 0.60
Thus, BDNF-LTP is associated with rapid and transient phosphorylation of two translation factors critical in controlling global translation initiation and elongation rates, eukaryotic initiation factor 4E (eIF4E), and elongation factor-2 (eEF2) [62].
Phosphorylation (phosphorylation) of eIF4E associated with long-term potentiation
2) Confidence 0.24 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0 Pain Relevance 0.50

General Comments

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