INT136788

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Eif4e) protein complex (Eif4e) cytoplasm (Eif4e)
Anatomy Link Frequency
dentate gyrus 1
Eif4e (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 43 99.92 Very High Very High Very High
antidepressant 28 94.04 High High
long-term potentiation 34 88.96 High High
Hippocampus 19 88.72 High High
depression 3 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
monoamine 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 3 29.40 Quite Low
Aids-related Complex 14 5.52 Low Low
Stress 4 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Amnesia 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Affective Disorder 1 5.00 Very Low Very Low Very Low
Convulsion 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effect of the selective serotonergic reuptake inhibitor fluoxetine on regulation of two major determinants of mRNA translation, eukaryotic initiation factor 4E (eIF4E) and eukaryotic elongation factor 2 (eEF2).
Regulation (regulation) of eukaryotic initiation factor 4E associated with fluoxetine
1) Confidence 0.61 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16817885 Disease Relevance 0 Pain Relevance 0.57
We examined the effect of the selective serotonergic reuptake inhibitor fluoxetine on regulation of two major determinants of mRNA translation, eukaryotic initiation factor 4E (eIF4E) and eukaryotic elongation factor 2 (eEF2).
Regulation (regulation) of eIF4E associated with fluoxetine
2) Confidence 0.61 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16817885 Disease Relevance 0 Pain Relevance 0.58
Chronic fluoxetine-treatment similarly modulates eIF4E and eEF2 activity in the dentate gyrus

[34].

Regulation (modulates) of eIF4E in dentate gyrus associated with fluoxetine
3) Confidence 0.18 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0 Pain Relevance 0.46

General Comments

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