INT136791

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 23.60
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Anatomy Link Frequency
lungs 2
macrophage 1
osteoblasts 1
muscle 1
fat pad 1
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 7 100.00 Very High Very High Very High
cytokine 314 99.76 Very High Very High Very High
Inflammation 296 99.44 Very High Very High Very High
chemokine 90 99.34 Very High Very High Very High
fibrosis 34 99.28 Very High Very High Very High
depression 5 98.12 Very High Very High Very High
Dopamine 61 87.76 High High
Kinase C 2 75.00 Quite High
cINOD 5 71.88 Quite High
Paracetamol 8 71.76 Quite High
Disease Link Frequency Relevance Heat
Bullous Skin Disease 60 100.00 Very High Very High Very High
Parkinson's Disease 22 100.00 Very High Very High Very High
Neurodegenerative Disease 17 100.00 Very High Very High Very High
Stroke 3 100.00 Very High Very High Very High
Infection 336 99.98 Very High Very High Very High
Targeted Disruption 409 99.96 Very High Very High Very High
Diabetes Mellitus 138 99.74 Very High Very High Very High
Injury 281 99.66 Very High Very High Very High
Syndrome 3 99.58 Very High Very High Very High
Atherosclerosis 14 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the OPN gene results in the reduction of migration
Negative_regulation (Inhibition) of OPN gene
1) Confidence 0.59 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.36 Pain Relevance 0
The suppression of OPN was seen to eliminate the ability of the PyV-mT cells to migrate in vitro, to colonize the lungs in tail vein injections, and to metastasize to the lungs in the mammary fat pad assay.
Negative_regulation (suppression) of OPN in fat pad associated with peripheral arterial disease
2) Confidence 0.51 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.30 Pain Relevance 0
We suggest that the potential mislocalization of OPN and potential reduction in secreted OPN in these cells may lead to protein complexes, which alter signaling pathways and increase the migratory behavior of the cells.
Negative_regulation (reduction) of OPN
3) Confidence 0.51 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.40 Pain Relevance 0
Relative OPN expression was determined by densitometry, indicating that OPN was reduced eightfold and was increased 3.5-fold in Met-As and in Db-S, respectively, compared with their vector control counterparts (Fig. 5b,5c).
Negative_regulation (reduced) of OPN
4) Confidence 0.51 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0 Pain Relevance 0
The overexpression of OPN correlates with an increased migration potential of cells, and the inhibition of OPN correlates with a decrease in migration.


Negative_regulation (inhibition) of OPN
5) Confidence 0.51 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.32 Pain Relevance 0
Furthermore, since basic research showed that OPN contributes to the development of nephropathy and atherosclerosis in diabetes [10,18-20], inhibition of OPN may become a novel therapeutic strategy for these paitents.


Negative_regulation (inhibition) of OPN associated with diabetes mellitus, atherosclerosis and renal disease
6) Confidence 0.51 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.43 Pain Relevance 0
However, whereas bacterial loads at 24 hours after infection were similar in OPN KO and WT mice, at 72 h post infection OPN deficiency was associated with an attenuated growth of B. pseudomallei in lungs and a tendency towards reduced dissemination.
Negative_regulation (deficiency) of OPN in lungs associated with targeted disruption and infection
7) Confidence 0.51 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 1.21 Pain Relevance 0
Osteopontin deficiency does not influence pulmonary cytokine concentrations
Negative_regulation (deficiency) of Osteopontin associated with cytokine
8) Confidence 0.43 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 0.81 Pain Relevance 0.44
The spatial expression pattern of Angiotensin II receptor is reminiscent of Osteopontin in the early inflammatory cluster, with the brightest staining in the deep dermal or muscle layer of the wild-type wound and only very faint expression seen at the PU.1 null wound site (Figure 7Bh,i).
Negative_regulation (reminiscent) of Osteopontin in muscle associated with inflammation and injury
9) Confidence 0.40 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.98 Pain Relevance 0.43
We suggest that the potential mislocalization of OPN and potential reduction in secreted OPN in these cells may lead to protein complexes, which alter signaling pathways and increase the migratory behavior of the cells.
Negative_regulation (reduction) of OPN
10) Confidence 0.38 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.41 Pain Relevance 0
Similar to a previous clinical study [28], we found that recovery from the acute phase was accompanied by a reduction in circulating OPN concentrations and that non-surviving patients had higher OPN levels on admission.
Negative_regulation (reduction) of OPN
11) Confidence 0.37 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 1.11 Pain Relevance 0
OPN deficiency did not impact on hepatocellular injury after infection with B. pseudomallei.
Negative_regulation (deficiency) of OPN associated with injury and infection
12) Confidence 0.37 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 1.72 Pain Relevance 0.32
Consistent with reduced bacterial outgrowth and diminished pulmonary tissue injury in OPN KO mice, OPN deficiency had a positive effect on survival.
Negative_regulation (deficiency) of OPN associated with targeted disruption and injury
13) Confidence 0.37 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 2.13 Pain Relevance 0
OPN deficiency did not influence the induction of proinflammatory cytokines.


Negative_regulation (deficiency) of OPN associated with cytokine
14) Confidence 0.37 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2930856 Disease Relevance 1.84 Pain Relevance 0.11
Approaches involving the inhibition of OPN signaling may prove valuable therapeutic strategies for the prevention of diabetic complications and improved patient outcomes.


Negative_regulation (inhibition) of OPN associated with diabetes complications
15) Confidence 0.37 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 0.92 Pain Relevance 0
In our model of melioidosis OPN did not impact on the release of other cytokines and chemokines with exception of KC, which was lower in OPN KO mice.
Negative_regulation (lower) of OPN associated with targeted disruption, chemokine, melioidosis and cytokine
16) Confidence 0.37 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 1.66 Pain Relevance 0.32
Except for KC levels, which were significantly decreased in OPN KO lungs as compared to WT at both timepoints, no significant differences between the two mouse strains were found at either timepoint (table 1).
Negative_regulation (decreased) of OPN in lungs associated with targeted disruption, sprains and strains and cytokine
17) Confidence 0.37 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 1.19 Pain Relevance 0.73
Our findings suggest that blockage of osteopontin and/or COX-2 is a promising therapeutic approach for the inhibition of prostate tumor progression and angiogenesis.
Negative_regulation (blockage) of osteopontin associated with prostate cancer
18) Confidence 0.28 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16818637 Disease Relevance 0.88 Pain Relevance 0.17
The timely resolution of myocardial remodeling is also confirmed by a lack of macrophage elastase [15] and osteopontin-1 staining after 7 days reperfusion.
Negative_regulation (lack) of osteopontin-1 in macrophage
19) Confidence 0.17 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2997608 Disease Relevance 0.42 Pain Relevance 0.17
NPP1 and PPi metabolism in pathologic soft tissue calcification syndromes and pivotal role of osteopontin depletion
Negative_regulation (depletion) of osteopontin associated with calcification and syndrome
20) Confidence 0.17 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.83 Pain Relevance 0.06

General Comments

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