INT136817

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (RHOA) mitochondrion (RHOA) cell morphogenesis (RHOA)
intracellular (RHOA) GTPase activity (RHOA) cytoplasm (RHOA)
RHOA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 82 99.74 Very High Very High Very High
Opioid 3 97.60 Very High Very High Very High
opiate 1 75.00 Quite High
Morphine 3 65.32 Quite High
antagonist 7 47.20 Quite Low
mu opioid receptor 1 46.76 Quite Low
cva 8 29.84 Quite Low
imagery 12 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 5 50.00 Quite Low
Increased Venous Pressure Under Development 15 48.16 Quite Low
Cancer 1 38.96 Quite Low
Cv General 3 Under Development 8 29.84 Quite Low
Hypertension 26 5.00 Very Low Very Low Very Low
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Atherosclerosis 19 5.00 Very Low Very Low Very Low
Thrombosis 18 5.00 Very Low Very Low Very Low
Stress 18 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, NO reportedly inhibits calcium sensitization by PKG-mediated inhibition of RhoA [34]–[35] and telokin [36], as well as by inhibition of RhoA activation through protein kinase A (PKA)-dependent phosphorylation of G?
Negative_regulation (inhibition) of Positive_regulation (activation) of RhoA
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0 Pain Relevance 0
Consistent with this, the specific PGD2 receptor (DP) agonist BW245C also significantly impaired RhoA activation (Fig. 7C) and cofilin phosphorylation in 1° h.AoSMCs.
Negative_regulation (impaired) of Positive_regulation (activation) of RhoA associated with agonist
2) Confidence 0.42 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.09
Taken together, these results indicate that MNTX inhibits opioid-induced EC proliferation and migration via inhibition of VEGF receptor phosphorylation/transactivation with subsequent inhibition of RhoA activation.
Negative_regulation (inhibition) of Positive_regulation (activation) of RhoA associated with opioid
3) Confidence 0.36 Published 2006 Journal Microvasc. Res. Section Abstract Doc Link 16820176 Disease Relevance 0 Pain Relevance 0.49
On the other hand, pre-stimulation with Cicaprost impaired U46619-induced [Ca2+]i mobilization and RhoA activation by TP?
Negative_regulation (impaired) of Positive_regulation (activation) of RhoA
4) Confidence 0.30 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.09
Moreover, Cicaprost (IP agonist) and BW245C (DP agonist) and the NO donors SIN-1 and FK409 each significantly impaired such U46619-induced RhoA activation, F-actin polymerization and cofilin phosphorylation in 1° h.AoSMCs.
Negative_regulation (impaired) of Positive_regulation (activation) of RhoA associated with agonist
5) Confidence 0.30 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.12
Consistent with this, the PGD2 receptor (DP) agonist BW245C also impaired RhoA activation by TP?
Negative_regulation (impaired) of Positive_regulation (activation) of RhoA associated with agonist
6) Confidence 0.30 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.12
Moreover, both SIN-1 and the alternative NO-donor FK409 also specifically impaired U46619-induced RhoA activation by TP?
Negative_regulation (impaired) of Positive_regulation (activation) of RhoA
7) Confidence 0.30 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
Similarly, while the NO donors SIN-1 and FK409 alone did not induce substantial RhoA signaling relative to the drug vehicle per se, they each significantly impaired U46619-induced RhoA activation and cofilin phosphorylation following their pre-incubation in 1° h.AoSMCs (Fig. 7B and D).
Negative_regulation (impaired) of Positive_regulation (activation) of RhoA
8) Confidence 0.30 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.08

General Comments

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