INT13683

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Context Info
Confidence 0.28
First Reported 1991
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 2.50
Pain Relevance 6.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a6) enzyme binding (Ugt1a6) protein complex (Ugt1a6)
Anatomy Link Frequency
spinal nerve 1
CPA 1
nerve 1
SON 1
body 1
Ugt1a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 20 100.00 Very High Very High Very High
Paracetamol 21 99.80 Very High Very High Very High
Eae 16 99.32 Very High Very High Very High
agonist 28 99.20 Very High Very High Very High
noradrenaline 12 98.96 Very High Very High Very High
allodynia 28 98.76 Very High Very High Very High
Spinal cord 10 98.08 Very High Very High Very High
adenocard 63 97.60 Very High Very High Very High
Dorsal horn 4 95.32 Very High Very High Very High
tetrodotoxin 1 94.96 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 16 100.00 Very High Very High Very High
Neuropathic Pain 42 98.76 Very High Very High Very High
Injury 12 97.48 Very High Very High Very High
Hepatocellular Cancer 2 91.56 High High
Fibrosarcoma 3 90.32 High High
Cancer 5 82.80 Quite High
Hyperalgesia 2 76.72 Quite High
Pain 5 74.32 Quite High
Nervous System Injury 6 73.96 Quite High
Osteoporosis 15 69.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (100 nM) significantly reduced the effect of CPA but did not change the effect of DPMA on the barium currents.
Neg (not) Regulation (change) of A1 in CPA associated with antagonist
1) Confidence 0.28 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9212255 Disease Relevance 0 Pain Relevance 0.91
This study was designed to determine the effects of the A1-receptor selective agonist N6-cyclopentyladenosine (CPA), and the A2-selective agonist, 2-p-(2-carboxyethyl)-phenethylamino-5'-N-ethylcarboxamidoadenosine-hydrochloride (CGS-21680) on consumptive behaviour and body temperature in rats in relation to the non-selective A1/A2 adenosine agonist, N-ethylcarboxamidoadenosine (NECA), and to morphine.
Spec (determine) Regulation (effects) of A1 in body associated with adenocard, agonist and morphine
2) Confidence 0.21 Published 2002 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11858214 Disease Relevance 0 Pain Relevance 0.41
These data are consistent with the proposal that NA, released from the SON terminals of A1 NA cells, acts via alpha 2-adrenoceptors to depress A1 transmitter release and thus A1 influence on VP cells.
Regulation (influence) of A1 in SON associated with noradrenaline
3) Confidence 0.21 Published 1993 Journal Brain Res. Section Abstract Doc Link 8394178 Disease Relevance 0 Pain Relevance 0.43
We have now investigated the possibility that NA released from A1 terminals acts presynaptically to modulate A1 input to VP cells.
Regulation (modulate) of A1 associated with noradrenaline
4) Confidence 0.21 Published 1993 Journal Brain Res. Section Abstract Doc Link 8394178 Disease Relevance 0 Pain Relevance 0.41
None of the 3 inhibitors of APAP glucuronidation were able to alter the expression of UGT1A6, UGT1A7 and UGT1A8 (the major isoforms responsible for APAP glucuronidation in the rat), however, their efficacy at inhibiting APAP glucuronidation was proportional to their capacity to deplete UDP-glucuronic acid (UDPGA).
Regulation (responsible) of UGT1A6 associated with paracetamol
5) Confidence 0.18 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18708084 Disease Relevance 0 Pain Relevance 0.96
In our experiment, we chose only the A1 antagonist DPCPX because the A1 receptor subtype was most effective in the reversal of mechanical allodynia in the nerve ligation injury model (7).
Regulation (effective) of A1 in nerve associated with allodynia, antagonist and injury
6) Confidence 0.15 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526387 Disease Relevance 0.54 Pain Relevance 1.06
It is reported that there was no evidence for up-regulation in spinal A1 receptors after spinal nerve ligation and that spinal cord adenosine was decreased after spinal nerve ligation (21).
Regulation (regulation) of A1 in spinal nerve associated with adenocard, eae and spinal cord
7) Confidence 0.13 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526387 Disease Relevance 0.44 Pain Relevance 1.50
Cytosolic GSH-S-transferase activity toward 1-chloro-2,4-dinitrobenzene was increased 52% by BSO, whereas p-nitrophenol sulfotransferase activity was not altered.
Neg (not) Regulation (altered) of p-nitrophenol sulfotransferase
8) Confidence 0.06 Published 1991 Journal Drug Metab. Dispos. Section Abstract Doc Link 1676661 Disease Relevance 0 Pain Relevance 0.59
There was a beneficial effect on Apo A1, a small decrease in HDL-cholesterol in one lasofoxifene group, and a 0.5 to 7.3% increase in median triglyceride levels.
Regulation (effect) of A1 associated with disorder of lipid metabolism
9) Confidence 0.02 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2773750 Disease Relevance 1.13 Pain Relevance 0.07
This is similar to the effect of A1, B1 (not shown) and C1 extract observed herein.
Regulation (effect) of A1
10) Confidence 0.02 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513146 Disease Relevance 0.39 Pain Relevance 0

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