INT136840

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.34
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctgf) cytosol (Ctgf) extracellular space (Ctgf)
extracellular region (Ctgf) cell adhesion (Ctgf) Golgi apparatus (Ctgf)
Anatomy Link Frequency
blood 1
connective tissue 1
Ctgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 2 99.18 Very High Very High Very High
Cannabinoid receptor 1 97.00 Very High Very High Very High
fibrosis 2 80.00 Quite High
medulla 4 40.88 Quite Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
GABA receptor 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 99.18 Very High Very High Very High
Cardiovascular Disease 2 99.12 Very High Very High Very High
Cancer 2 98.24 Very High Very High Very High
Hypertension 38 95.76 Very High Very High Very High
Aging 4 95.20 Very High Very High Very High
Malaria 1 82.68 Quite High
Stroke 1 82.08 Quite High
Benign Prostatic Hypertrophy 1 81.44 Quite High
Overactive Bladder 1 80.24 Quite High
Fibrosis 2 80.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CTGF is induced in adult SHR and is reduced by antihypertensive treatments [7], suggesting that CTGF expression is dependent on blood pressure.
Positive_regulation (induced) of CTGF in blood
1) Confidence 0.35 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.41 Pain Relevance 0.04
CTGF and Ptger2 were increased in SHR vs.
Positive_regulation (increased) of CTGF
2) Confidence 0.23 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.05 Pain Relevance 0
During these discussions, the following possible drug targets were considered: urothelium-derived inhibitory factor, muscarinic receptors in the bladder, purinergic signaling, pacemaking cells in the urogenital tract, cannabinoid receptors in the prostate, vascular endothelial growth factor in cancer, the nonselective cation channel TPRV1 in pain, and angiotensin receptors, Rho kinase, connective tissue growth factor and NADPH oxidase in cardiovascular disease.
Positive_regulation (connective) of tissue growth factor in connective tissue associated with pain, cannabinoid receptor, cardiovascular disease and cancer
3) Confidence 0.04 Published 2006 Journal Drug News Perspect. Section Abstract Doc Link 16823499 Disease Relevance 0.87 Pain Relevance 0.23

General Comments

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