INT136850

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 17
Disease Relevance 6.96
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Arg1) aging (Arg1) cytoplasm (Arg1)
Anatomy Link Frequency
plasma 1
macrophage 1
liver 1
vagina 1
immune system 1
Arg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 182 100.00 Very High Very High Very High
tolerance 6 100.00 Very High Very High Very High
cytokine 18 96.60 Very High Very High Very High
Inflammation 47 92.76 High High
cryotherapy 76 90.32 High High
cerebral cortex 48 86.16 High High
Hippocampus 9 83.60 Quite High
corticosteroid 70 76.28 Quite High
noradrenaline 2 72.72 Quite High
Analgesic 2 59.56 Quite High
Disease Link Frequency Relevance Heat
Rhabdomyolysis 1 99.84 Very High Very High Very High
Reperfusion Injury 16 99.40 Very High Very High Very High
Hypoxia 504 99.08 Very High Very High Very High
Acute Renal Failure 9 98.92 Very High Very High Very High
Stress 78 93.80 High High
Occupational Lung Diseases 2 93.44 High High
INFLAMMATION 49 92.76 High High
Infection 29 92.00 High High
Diabetes Mellitus 4 79.92 Quite High
Insulin Resistance 4 78.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Melatonin reduces nitric oxide via increasing arginase in rhabdomyolysis-induced acute renal failure in rats.
Positive_regulation (increasing) of arginase associated with acute renal failure and rhabdomyolysis
1) Confidence 0.50 Published 2006 Journal Ren Fail Section Title Doc Link 16825094 Disease Relevance 0.74 Pain Relevance 0.05
Tamoxifen treatment increased ER levels in the vagina and decreased arginase activity (figures 4 &5).
Positive_regulation (increased) of arginase in vagina
2) Confidence 0.30 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0 Pain Relevance 0
Similar changes in ER binding and arginase activity were observed in vaginal tissue extracts of ovariectomized rats.
Positive_regulation (changes) of arginase
3) Confidence 0.30 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0 Pain Relevance 0
The mechanism of increased activity of arginase in reperfusion is not known and may be up regulated with the supply of oxygen.
Positive_regulation (increased) of arginase
4) Confidence 0.20 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.22 Pain Relevance 0.12
Hence the decreased GS and increased arginase activities may be protective in reperfusion group.
Positive_regulation (increased) of arginase
5) Confidence 0.20 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.62 Pain Relevance 0.23
The increased activity of arginase in reperfusion group may be beneficial by the way of competing NOS for arginine.
Positive_regulation (increased) of arginase
6) Confidence 0.20 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.59 Pain Relevance 0.26
However the observed increase of arginase in reperfusion group may favor decreased production of NO in this condition.
Positive_regulation (increase) of arginase
7) Confidence 0.18 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.24 Pain Relevance 0.10
Apart from NO synthesis L-arginine may also serve as a substrate for glutamate formation and may also provide increased substrate for arginase 50.
Positive_regulation (increased) of arginase associated with glutamate
8) Confidence 0.15 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.24 Pain Relevance 0.05
However in reperfusion group arginase activity was significantly increased and that may be responsible to curtail the supply of arginine for NO production in reperfusion.
Positive_regulation (increased) of arginase
9) Confidence 0.12 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.87 Pain Relevance 0.04
The increased arginase and sustained decrease of GS activity in reperfusion group are likely to be protective.



Positive_regulation (increased) of arginase
10) Confidence 0.12 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.78 Pain Relevance 0.09
The increased arginase and sustained decrease of GS activity in reperfusion group likely to be protective.



Positive_regulation (increased) of arginase
11) Confidence 0.12 Published 2010 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC2880843 Disease Relevance 0.63 Pain Relevance 0.03
Urea synthesis alone requires five enzymes (arginosuccinate lyase, arginosuccinate synthetase, arginase, ornithine transcarbamoylase, and carbamoyl phosphate synthetase).
Positive_regulation (requires) of arginase
12) Confidence 0.12 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0.61 Pain Relevance 0.15
However, similar to genes in Class 1 (ASS and MDH), we observed a lack of tolerance in arginase (ARG) and GDH.
Positive_regulation (tolerance) of arginase associated with tolerance
13) Confidence 0.10 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.08
Arginase activation may also result from a direct interaction of trypanosome products on cells of the immune system causing the production of polyamines, which are essential for trypanothion synthesis, and therefore for the growth and survival of trypanosomes [25].
Positive_regulation (activation) of Arginase in immune system
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0.55 Pain Relevance 0.40
It could be speculated that when EDTA was omitted from an incubation medium, exogenous arginine likely stimulate the activity of manganese-dependent arginase there through limiting an availability of arginine for NO synthesis likewise it has been demonstrated in macrophage cultures [24].
Positive_regulation (stimulate) of arginase in macrophage
15) Confidence 0.03 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0
Statistically significant increases in the activities of glutamate dehydrogenase, sorbitol dehydrogenase, malate dehydrogenase, ornithine transcarbamoylase, and arginase were observed in the plasma and liver.
Positive_regulation (increases) of arginase in plasma associated with glutamate
16) Confidence 0.01 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734249 Disease Relevance 0.44 Pain Relevance 0.43
Statistically significant increases in the activities of glutamate dehydrogenase, sorbitol dehydrogenase, malate dehydrogenase, ornithine transcarbamoylase, and arginase were observed in the plasma and liver.
Positive_regulation (increases) of arginase in liver associated with glutamate
17) Confidence 0.00 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734249 Disease Relevance 0.44 Pain Relevance 0.43

General Comments

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