INT136851

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.05
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Arg1) aging (Arg1) cytoplasm (Arg1)
Anatomy Link Frequency
macrophages 1
blood 1
vagina 1
kidney 1
Arg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 35 100.00 Very High Very High Very High
anesthesia 4 95.52 Very High Very High Very High
Bioavailability 1 92.88 High High
Inflammation 8 81.80 Quite High
Pain 9 43.64 Quite Low
Glutamate 24 37.44 Quite Low
addiction 1 33.60 Quite Low
endometriosis 3 21.04 Low Low
antagonist 9 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 63 98.00 Very High Very High Very High
Acute Renal Failure 18 97.80 Very High Very High Very High
Sprains And Strains 3 91.44 High High
Reprotox - General 2 15 91.28 High High
INFLAMMATION 9 81.80 Quite High
Rhabdomyolysis 2 75.00 Quite High
Breast Cancer 33 67.40 Quite High
Endometriosis (extended) 15 66.12 Quite High
Stress 12 50.00 Quite Low
Pain 9 43.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, the authors aimed to investigate the effect of melatonin on arginase activity, ornithine, and NO levels on the myoglobinuric ARF formed by intramuscular (i.m.) injection of hypertonic glycerol.
Spec (investigate) Regulation (effect) of arginase associated with acute renal failure
1) Confidence 0.38 Published 2006 Journal Ren Fail Section Abstract Doc Link 16825094 Disease Relevance 0.83 Pain Relevance 0.06
Similar changes in ER binding and arginase activity were observed in vaginal tissue extracts of ovariectomized rats.
Regulation (changes) of arginase
2) Confidence 0.29 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0 Pain Relevance 0
Melatonin had an increasing effect on kidney tissue arginase activities and ornithine levels while decreasing NO concentration.
Regulation (effect) of arginase in kidney
3) Confidence 0.20 Published 2006 Journal Ren Fail Section Abstract Doc Link 16825094 Disease Relevance 0.79 Pain Relevance 0.10
In the present study, the tamoxifen-induced changes in vaginal blood flow, ER expression and arginase activity were similar to those in ovariectomized animals and markedly differed from the control group.
Regulation (changes) of arginase in blood
4) Confidence 0.18 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0 Pain Relevance 0
We further assessed changes in ER expression and arginase activity as estrogen-dependent markers in the vagina.


Regulation (changes) of arginase in vagina
5) Confidence 0.18 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0.49 Pain Relevance 0
As has been mentioned in the previous section, the coordinated regulation of CS on CPS (the first enzyme of the ornithine cycle, converts ammonia, originating from amino acid degradation, into urea) or arginase (the last enzyme of the cycle) via CEBP-?
Regulation (regulation) of arginase associated with corticosteroid
6) Confidence 0.14 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.13
The activity of arginase (Figure 2) showed no significant change, indicating there was no increased utilization of arginine by this enzyme in anoxia.
Neg (no) Regulation (change) of arginase associated with hypoxia
7) Confidence 0.08 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.95 Pain Relevance 0.04
Although, the unique and relatively potent inhibition of arginase by the biosynthetic intermediate in NO generation, NG-hydroxy-L-arginine suggests an alternate means of regulation in tissues and cells (such as macrophages), that contain both NOS and arginase [35].
Regulation (regulation) of arginase in macrophages
8) Confidence 0.01 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0.05

General Comments

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