INT136860

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 11
Disease Relevance 4.53
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Fabp3) cytosol (Fabp3) mitochondrion (Fabp3)
cytoplasm (Fabp3)
Anatomy Link Frequency
blood 1
fat 1
chest 1
adipose tissue 1
Fabp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 336 99.98 Very High Very High Very High
tolerance 7 95.32 Very High Very High Very High
Angina 10 94.68 High High
metalloproteinase 1 71.72 Quite High
Inflammation 1 68.52 Quite High
anesthesia 7 5.00 Very Low Very Low Very Low
isoflurane 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 42 99.60 Very High Very High Very High
Myocardial Infarction 19 98.68 Very High Very High Very High
Death 4 98.44 Very High Very High Very High
Impaired Glucose Tolerance 7 95.32 Very High Very High Very High
Left Ventricular Hypertrophy 1 95.28 Very High Very High Very High
Angina 6 94.68 High High
Heart Disease 2 94.04 High High
Diabetes Mellitus 91 89.68 High High
Dyslipidemia /

Combined Dyslipidemia

28 88.92 High High
Insulin Resistance 84 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with GI262570 dose-dependently upregulated adipose FABP3 mRNA, and increased serum adiponectin.
Positive_regulation (upregulated) of FABP3 mRNA
1) Confidence 0.60 Published 2004 Journal BMC Pharmacol Section Abstract Doc Link PMC526775 Disease Relevance 0.28 Pain Relevance 0.30
When a test line appeared within 15 min after the addition of 150 microL of whole blood, it was designated to be positive for H-FABP.
Positive_regulation (positive) of H-FABP in blood
2) Confidence 0.43 Published 2006 Journal J Immunoassay Immunochem Section Abstract Doc Link 16827225 Disease Relevance 0.79 Pain Relevance 0.09
agonist GI262570 upregulated serum adiponectin level and adipose FABP3 mRNA level in SD rats in a dose-dependent manner.
Positive_regulation (upregulated) of FABP3 mRNA associated with agonist
3) Confidence 0.40 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.35 Pain Relevance 0.17
agonist-upregulated fatty acid binding protein(FABP3) mRNA in adipose tissue and PPAR?
Positive_regulation (upregulated) of FABP3 in adipose tissue associated with obesity and agonist
4) Confidence 0.40 Published 2004 Journal BMC Pharmacol Section Abstract Doc Link PMC526775 Disease Relevance 0.28 Pain Relevance 0.30
As showed in Fig. 1, treatment of SD rats on HF diet with GI262570 for 2 weeks dose-dependently increased serum adiponectin, and upregulated adipose FABP3 mRNA without effect on housekeeper genes 18S, ?
Positive_regulation (upregulated) of FABP3 mRNA
5) Confidence 0.40 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.16 Pain Relevance 0.20
full agonist-upregulated serum adiponectin level and adipose FABP3 mRNA level, demonstrating the serum adiponectin level could be a biomarker for in vivo PPAR?
Positive_regulation (upregulated) of FABP3 mRNA associated with agonist
6) Confidence 0.40 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.27 Pain Relevance 0.17
Therefore the authors consider that the dose-dependently GI262570 upregulated FABP3 mRNA in epididymal fat caught in the present study is of value for quantitative in vivo PPAR?
Positive_regulation (upregulated) of FABP3 mRNA in fat
7) Confidence 0.40 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.05 Pain Relevance 0.15
agonist GI262570 dose-dependently increased FABP3 mRNA.
Positive_regulation (increased) of FABP3 mRNA associated with agonist
8) Confidence 0.40 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.11 Pain Relevance 0.23
The automated H-FABP (by LTIA) is superior to cTnT, CK-MB, myoglobin, and H-FABP (by ELISA) tests for the diagnosis of AMI in patients admitted within 4 hours from the onset of chest pain.
Positive_regulation (automated) of H-FABP in chest associated with angina and myocardial infarction
9) Confidence 0.35 Published 2010 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 20551280 Disease Relevance 0.57 Pain Relevance 0.09
Patients without elevations of H-FABP, NT-pro-BNP, or peak cTnT formed a very low risk group in terms of death or MI within 1 year.
Neg (without) Positive_regulation (elevations) of H-FABP associated with myocardial infarction and death
10) Confidence 0.25 Published 2009 Journal Am. J. Cardiol. Section Abstract Doc Link 19101224 Disease Relevance 1.30 Pain Relevance 0.27
Serum hs-CRP [(7.64 +/- 2.18) mg/L vs. (1.78 +/- 0.62) mg/L, P < 0.001], h-FABP [(16.46 +/- 5.28) microg/L vs. (3.15 +/- 2.61) microg/L, P < 0.001] and cTn-I [(1.28 +/- 0.43) microg/L vs. (0.67 +/- 0.09) microg/L, P < 0.001] levels were also significantly higher in UAP group than those in SAP group.
Positive_regulation (higher) of h-FABP
11) Confidence 0.10 Published 2006 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Body Doc Link 17217689 Disease Relevance 0.16 Pain Relevance 0

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