INT136864

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.43
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Pebp1) mitochondrion (Pebp1) extracellular space (Pebp1)
Golgi apparatus (Pebp1) cytoplasm (Pebp1)
Anatomy Link Frequency
livers 1
parenchymal cells 1
Pebp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 3 74.40 Quite High
addiction 1 25.00 Low Low
agonist 9 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Embryonic Lethality 2 99.20 Very High Very High Very High
Placental Insufficiency 1 98.12 Very High Very High Very High
Hepatomegaly 1 75.04 Quite High
Necrosis 1 59.76 Quite High
Paralysis 1 38.80 Quite Low
Hepatotoxicity 1 35.84 Quite Low
Ovarian Cancer 9 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Obesity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adenoviral expression of both PBP and EGFP-CAR restored phenobarbital-mediated nuclear translocation of exogenously expressed CAR in PBP null livers in vivo and in PBP null primary hepatocytes in vitro.
Gene_expression (expression) of PBP in livers
1) Confidence 0.59 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.06 Pain Relevance 0.14
Targeted deletion of coactivator PBP gene in liver parenchymal cells (PBP(LIV-/-)) results in the near abrogation of the induction of PPARalpha and CAR (constitutive androstane receptor)-regulated genes in liver.
Gene_expression (deletion) of PBP in parenchymal cells
2) Confidence 0.30 Published 2007 Journal Gene Expr. Section Abstract Doc Link 17605299 Disease Relevance 0.17 Pain Relevance 0
Although these coactivators also bind other steroid receptors, deletion of the PBP gene in mice results in embryonic lethality due to placental insufficiency [37], the same results seen in PPAR?
Gene_expression (gene) of PBP associated with placental insufficiency and embryonic lethality
3) Confidence 0.05 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.20 Pain Relevance 0

General Comments

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