INT136865

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.24
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Casr) plasma membrane (Casr) signal transducer activity (Casr)
Anatomy Link Frequency
livers 4
CAR 2
Casr (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 6 96.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 3 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CAR translocation into the nucleus of PRIP null livers resulted in the induction of CAR target genes such as CYP2B10, necessary for the conversion of acetaminophen to its hepatotoxic intermediate metabolite, N-acetyl-p-benzoquinone imine.
Positive_regulation (resulted) of Localization (translocation) of CAR in livers associated with paracetamol
1) Confidence 0.47 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.08 Pain Relevance 0.18
These results establish that transcription coactivator PBP plays a pivotal role in nuclear localization of CAR, that it is likely that PBP either enhances nuclear import or nuclear retention of CAR in hepatocytes, and that PRIP is redundant for CAR function.
Spec (likely) Positive_regulation (enhances) of Localization (retention) of CAR in CAR
2) Confidence 0.47 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.09 Pain Relevance 0.18
Adenoviral expression of both PBP and EGFP-CAR restored phenobarbital-mediated nuclear translocation of exogenously expressed CAR in PBP null livers in vivo and in PBP null primary hepatocytes in vitro.
Positive_regulation (restored) of Localization (translocation) of CAR in livers
3) Confidence 0.44 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.07 Pain Relevance 0.15

General Comments

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