INT136869

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nr1i3) cytoskeleton (Nr1i3) nucleus (Nr1i3)
DNA binding (Nr1i3) cytoplasm (Nr1i3)
Anatomy Link Frequency
CAR 1
liver 1
Nr1i3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 3 92.56 High High
addiction 1 85.36 High High
Disease Link Frequency Relevance Heat
Hepatotoxicity 1 93.48 High High
Paralysis 1 91.80 High High
Hepatomegaly 1 73.80 Quite High
Embryonic Lethality 1 55.84 Quite High
Necrosis 1 46.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies with adenovirally driven EGFP-CAR expression in liver demonstrated that, unlike PBP, the absence of PRIP does not prevent phenobarbital-mediated nuclear translocation/retention of the receptor CAR in liver in vivo and cultured hepatocytes in vitro.
Localization (translocation/retention) of CAR in CAR
1) Confidence 0.43 Published 2007 Journal Gene Expr. Section Abstract Doc Link 17605299 Disease Relevance 0.31 Pain Relevance 0.14
Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver.
Localization (translocation) of constitutive androstane receptor in liver
2) Confidence 0.42 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 16828057 Disease Relevance 0 Pain Relevance 0.05

General Comments

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