INT136904

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2008
Negated 1
Speculated 3
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 3.71
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC18A3) transmembrane transport (SLC18A3)
Anatomy Link Frequency
tendons 3
row 1
SLC18A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 205 100.00 Very High Very High Very High
Catecholamine 25 100.00 Very High Very High Very High
Serotonin 10 100.00 Very High Very High Very High
Neurotransmitter 155 98.88 Very High Very High Very High
Pain 11 98.72 Very High Very High Very High
Glutamate 125 98.00 Very High Very High Very High
substance P 120 86.24 High High
Calcitonin gene-related peptide 55 81.20 Quite High
GABAergic 35 78.16 Quite High
Neuropeptide 30 59.28 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 95 100.00 Very High Very High Very High
Tendinopathy 26 99.32 Very High Very High Very High
Pain 6 97.66 Very High Very High Very High
Hyperplasia 2 69.04 Quite High
INFLAMMATION 10 15.00 Low Low
Disease 25 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 15 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As ChAT and VAChT immunoreactions were detected in tenocytes of tendinosis tendons, these cells might be a source of local acetylcholine (Ach) production.
Gene_expression (detected) of VAChT in tendons associated with tendinopathy
1) Confidence 0.68 Published 2006 Journal Microsc. Res. Tech. Section Abstract Doc Link 16830327 Disease Relevance 0.67 Pain Relevance 0.25
We have studied pain-free normal Achilles tendons and chronically painful Achilles tendinosis tendons with regard to immunohistochemical expression patterns of the M(2) muscarinic acetylcholine receptor (M(2)R), choline acetyltransferase (ChAT), and vesicular acetylcholine transporter (VAChT).
Gene_expression (expression) of VAChT in tendons associated with pain and tendinopathy
2) Confidence 0.67 Published 2008 Journal Cell Tissue Res. Section Abstract Doc Link 17999088 Disease Relevance 0.54 Pain Relevance 0.20
We have studied pain-free normal Achilles tendons and chronically painful Achilles tendinosis tendons with regard to immunohistochemical expression patterns of the M(2) muscarinic acetylcholine receptor (M(2)R), choline acetyltransferase (ChAT), and vesicular acetylcholine transporter (VAChT).
Gene_expression (expression) of vesicular acetylcholine transporter in tendons associated with pain and tendinopathy
3) Confidence 0.58 Published 2008 Journal Cell Tissue Res. Section Abstract Doc Link 17999088 Disease Relevance 0.54 Pain Relevance 0.20
In summary, a population of D12 cells was found to express GAD, whereas the rate-limiting enzymes in catecholamine and serotonin biosynthesis, and the acetylcholine transporter, were not detected.
Neg (not) Gene_expression (detected) of acetylcholine transporter associated with gaba, catecholamine and serotonin
4) Confidence 0.38 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.75 Pain Relevance 0.98
In contrast, a light band was detectable in D12 extracts for GAD (third row, far right column, white bar) and D0 extracts for VAChT (fourth row, far left column, gray bar).
Gene_expression (extracts) of VAChT in row associated with gaba
5) Confidence 0.33 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.51 Pain Relevance 0.79
To this end, expression of the rate-limiting enzymes in catecholamine (TyrH), serotonin (TrypH) and GABA (GAD) biosynthesis, as well as the vesicular acetylcholine transporter (VAChT), were examined in uninduced (D0) and induced (D6 and D12) MSCs (Fig. 2A).
Spec (examined) Gene_expression (expression) of acetylcholine transporter associated with gaba, catecholamine and serotonin
6) Confidence 0.29 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.23 Pain Relevance 0.67
To this end, expression of the rate-limiting enzymes in catecholamine (TyrH), serotonin (TrypH) and GABA (GAD) biosynthesis, as well as the vesicular acetylcholine transporter (VAChT), were examined in uninduced (D0) and induced (D6 and D12) MSCs (Fig. 2A).
Spec (examined) Gene_expression (biosynthesis) of VAChT associated with gaba, catecholamine and serotonin
7) Confidence 0.29 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.23 Pain Relevance 0.65
To this end, expression of the rate-limiting enzymes in catecholamine (TyrH), serotonin (TrypH) and GABA (GAD) biosynthesis, as well as the vesicular acetylcholine transporter (VAChT), were examined in uninduced (D0) and induced (D6 and D12) MSCs (Fig. 2A).
Spec (examined) Gene_expression (expression) of VAChT associated with gaba, catecholamine and serotonin
8) Confidence 0.29 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.23 Pain Relevance 0.67

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