INT136920

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 8.25
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOTCH1) nucleoplasm (NOTCH1) extracellular region (NOTCH1)
Golgi apparatus (NOTCH1) plasma membrane (NOTCH1) nucleus (NOTCH1)
Anatomy Link Frequency
Notch 8
cleavage 2
PC-3 2
NOTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 1 89.20 High High
Multiple sclerosis 123 88.28 High High
Neurotransmitter 1 87.12 High High
Demyelination 3 86.28 High High
tetrodotoxin 1 84.72 Quite High
chemokine 4 79.08 Quite High
sodium channel 1 78.28 Quite High
Neuritis 1 71.04 Quite High
Potency 4 27.04 Quite Low
cINOD 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 148 100.00 Very High Very High Very High
Disease 145 100.00 Very High Very High Very High
Thyroid Neoplasm 326 99.84 Very High Very High Very High
Cancer 246 95.56 Very High Very High Very High
Cytomegalovirus Infection 1 93.28 High High
Manic Depressive Disorder 2 92.40 High High
Carcinoid 2 89.64 High High
Small Cell Lung Cancer 4 88.72 High High
Lung Cancer 6 88.48 High High
Demyelinating Disease 126 88.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mediators have been joined by others including Notch/Delta, semaphorin, ephrin,
Positive_regulation (including) of Gene_expression (others) of Notch in Notch
1) Confidence 0.49 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.54 Pain Relevance 0.04
mediators have been joined by others including Notch/Delta, semaphorin, ephrin,
Positive_regulation (including) of Gene_expression (/) of Notch in Notch
2) Confidence 0.49 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.54 Pain Relevance 0.04
In fact, it was prevented by the inhibition of the proteolytic gamma-secretase enzyme or the transcription machinery, and was mimicked by the transfection of the intracellular domain of Notch.
Positive_regulation (transfection) of Gene_expression (transfection) of Notch in Notch
3) Confidence 0.49 Published 2009 Journal Dev Neurobiol Section Abstract Doc Link 19263417 Disease Relevance 0.45 Pain Relevance 0.16
Overexpression of the Notch1 intracellular domain in MTC
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Notch1 associated with thyroid neoplasm
4) Confidence 0.45 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.43 Pain Relevance 0
In contrast, the Notch ligand Delta-like1 (Dll1) levels were higher in LNCaP compared with PC-3 and PC-3M cells.
Positive_regulation (higher) of Gene_expression (levels) of Notch in PC-3
5) Confidence 0.43 Published 2006 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16832382 Disease Relevance 0.31 Pain Relevance 0.12
Using a doxycycline-inducible NICD in MTC cells (TT cells), we have recently shown that overexpression of Notch1 in MTC cells – Notch1 signaling is normally absent in MTC cells – results in a dose-dependent reduction in NE tumor markers and growth (Kunnimalaiyaan et al 2006, 2007a; Kunnimalaiyaan and Chen 2007).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Notch1 associated with thyroid neoplasm and cancer
6) Confidence 0.30 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.79 Pain Relevance 0
Recent data confirm that the N294S mutation, and the H274Y mutation that confers high level resistance to oseltamivir, are rare in circulating H5N1 viruses; of 676 isolates, only 1 contained N294S and 4 contained H274Y.71
Positive_regulation (circulating) of Gene_expression (viruses) of H5N1
7) Confidence 0.05 Published 2010 Journal Journal of Antimicrobial Chemotherapy Section Body Doc Link PMC2835509 Disease Relevance 0.48 Pain Relevance 0
Hoffmann-La Roche Ltd) is recommended on the basis of observational data and systemic activity by the WHO as the primary treatment for H5N1 infection, with particular potential for reducing mortality if used in the early stages of disease.32,33 Oseltamivir also appears active in the attempts to control disease outbreaks caused by H7 avian viruses.34,35

Treatment experience

Positive_regulation (treatment) of Gene_expression (infection) of H5N1 associated with disease and infection
8) Confidence 0.05 Published 2010 Journal Journal of Antimicrobial Chemotherapy Section Body Doc Link PMC2835509 Disease Relevance 1.25 Pain Relevance 0
Resistance to oseltamivir in H5N1 viruses
Positive_regulation (viruses) of Gene_expression (Resistance) of H5N1
9) Confidence 0.05 Published 2010 Journal Journal of Antimicrobial Chemotherapy Section Body Doc Link PMC2835509 Disease Relevance 0.53 Pain Relevance 0
Hoffmann-La Roche Ltd) is recommended on the basis of observational data and systemic activity by the WHO as the primary treatment for H5N1 infection, with particular potential for reducing mortality if used in the early stages of disease.32,33 Oseltamivir also appears active in the attempts to control disease outbreaks caused by H7 avian viruses.34,35

Treatment experience

Positive_regulation (by) of Gene_expression (infection) of H5N1 associated with disease and infection
10) Confidence 0.05 Published 2010 Journal Journal of Antimicrobial Chemotherapy Section Body Doc Link PMC2835509 Disease Relevance 1.23 Pain Relevance 0
To examine this cleavage, cell lines were seeded in 6 well dishes at 6 × 105 cells per ml (2 ml/well) and each well was transfected with 6.25 ng Notch ?
Positive_regulation (transfected) of Gene_expression (transfected) of Notch in cleavage
11) Confidence 0.04 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.09 Pain Relevance 0
Additionally, animal models have shown that elevated expression of Notch and jagged-1 expression does not appear to be a limiting factor in remyelination, but the animal model study reports that there were no quantitative differences in Notch1 expressing cells in slow and rapidly remyelinating lesions, indicating that Notch–Jagged signaling is not a rate-limiting determinant of remyelination in rodent models of demyelination [24].
Positive_regulation (elevated) of Gene_expression (expression) of Notch in Notch associated with demyelination
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 0.59 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox