INT136921

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.27
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOTCH3) nucleoplasm (NOTCH3) extracellular region (NOTCH3)
plasma membrane (NOTCH3) nucleus (NOTCH3)
Anatomy Link Frequency
Notch 1
alveolar cell 1
PNT2 1
lung 1
NOTCH3 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 1 92.72 High High
imagery 4 66.12 Quite High
tetrodotoxin 1 54.72 Quite High
Somatostatin 6 19.16 Low Low
depression 8 6.48 Low Low
Migraine 24 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 9 99.86 Very High Very High Very High
Hyperplasia 6 98.96 Very High Very High Very High
Reprotox - General 1 4 97.48 Very High Very High Very High
Lung Cancer 228 95.44 Very High Very High Very High
Cadasil 36 94.52 High High
Genomic Instability 27 89.28 High High
Genetic Translocation 3 87.76 High High
Cancer 258 86.44 High High
Chromosome Aberrations 18 82.76 Quite High
Cognitive Disorder 8 78.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutation analysis of the NOTCH3 gene
Gene_expression (gene) of NOTCH3
1) Confidence 0.67 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2190758 Disease Relevance 0.47 Pain Relevance 0.03
DNA from patients and their families was amplified using primers designed to amplify the 33 exons, including the intron-exon boundaries, of the NOTCH3 gene.
Gene_expression (boundaries) of NOTCH3
2) Confidence 0.67 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2190758 Disease Relevance 0.44 Pain Relevance 0.03
Notch1 and Notch2 were differentially expressed in PCa cell lines of varying metastatic potential (LNCaP, PC-3, PC-3M) in comparison to a normal prostate cell line (PNT2), whereas Notch3 and Notch4 were not expressed.
Neg (not) Gene_expression (expressed) of Notch3 in PNT2 associated with reprotox - general 1
3) Confidence 0.63 Published 2006 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16832382 Disease Relevance 0.35 Pain Relevance 0.10
These data suggest that Notch3 overexpression prevents epithelial differentiation and this may play a significant role in promoting oncogenesis in a subset of lung cancers [54].


Gene_expression (overexpression) of Notch3 in lung associated with lung cancer
4) Confidence 0.36 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 1.03 Pain Relevance 0
The authors developed a transgenic mouse model overexpressing Notch 3 causing neonatal mortality with a phenotype suggestive of alveolar cell hyperplasia.
Gene_expression (overexpressing) of Notch 3 in alveolar cell associated with targeted disruption and hyperplasia
5) Confidence 0.36 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 0.99 Pain Relevance 0
Recently, Dang et al. identified a chromosome 19–15 translocation associated with overexpression of Notch 3 [53].
Gene_expression (overexpression) of Notch 3 in Notch
6) Confidence 0.36 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 0.98 Pain Relevance 0

General Comments

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