INT136925

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.56
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NOTCH2) cytosol (NOTCH2) nucleoplasm (NOTCH2)
extracellular region (NOTCH2) plasma membrane (NOTCH2) nucleus (NOTCH2)
Anatomy Link Frequency
PNT2 1
NOTCH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 1 99.48 Very High Very High Very High
tetrodotoxin 1 41.20 Quite Low
cINOD 12 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 4 99.84 Very High Very High Very High
Disease 36 72.36 Quite High
Adhesions 4 55.40 Quite High
Alzheimer's Dementia 20 50.00 Quite Low
Stress 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notch1 and Notch2 were differentially expressed in PCa cell lines of varying metastatic potential (LNCaP, PC-3, PC-3M) in comparison to a normal prostate cell line (PNT2), whereas Notch3 and Notch4 were not expressed.
Gene_expression (expressed) of Notch2 in PNT2 associated with reprotox - general 1
1) Confidence 0.61 Published 2006 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16832382 Disease Relevance 0.37 Pain Relevance 0.05
It is of interest that while OSBP1 overexpression produced no obvious changes in the localization of APP, an altered localization of APP-Notch2 dimers was detected.
Gene_expression (overexpression) of Notch2
2) Confidence 0.39 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
When OSBP1 was not overexpressed, 25OH had no effect on the localization of the APP-Notch2 dimers, perhaps because basal levels of OSBP1 were not high enough to counteract the effects of 25OH binding to other ORPs or LXRs.
Neg (not) Gene_expression (overexpressed) of Notch2
3) Confidence 0.39 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
Using BiFC we demonstrated that OSBP1 appeared to modulate the distribution of APP-Notch2 heterodimers (Figure 5A).
Gene_expression (distribution) of Notch2
4) Confidence 0.39 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
In this particular study our investigation was limited to APP-Notch2 heterodimers; however, this is likely only a small proportion of the total population of APP heterodimers, and it is possible that OSBP1 could also affect the intracellular trafficking of other types of APP heterodimers.
Gene_expression (heterodimers) of Notch2
5) Confidence 0.39 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.07 Pain Relevance 0

General Comments

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