INT136933

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.42
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Urb1)
Urb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 4 99.68 Very High Very High Very High
Analgesic 2 99.68 Very High Very High Very High
agonist 6 99.56 Very High Very High Very High
antagonist 5 99.24 Very High Very High Very High
Morphine 5 97.28 Very High Very High Very High
Endocannabinoid 2 90.76 High High
narcan 3 88.96 High High
Antinociceptive 1 87.68 High High
withdrawal 2 86.48 High High
Root ganglion neuron 1 86.32 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 85.92 High High
Anxiety Disorder 2 65.88 Quite High
Pain 3 56.32 Quite High
Nociception 1 55.60 Quite High
Catalepsy 1 53.80 Quite High
Hypothermia 1 53.36 Quite High
Hyperphagia 1 52.84 Quite High
Toxicity 2 31.04 Quite Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the conditioned floor preference procedure (Expts 2a-d), rats trained to associate morphine with one of two distinctive floors were administered one of several doses of the CB(1) antagonist/inverse agonist, AM-251 (Expt 2a) or URB-597 (Expt 2b and 2d) prior to each extinction/test trial wherein a choice of both floors was presented and prior to forced exposure to each floor (Expt 2c).
Gene_expression (presented) of URB-597 associated with antagonist, agonist and morphine
1) Confidence 0.51 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19698735 Disease Relevance 0 Pain Relevance 0.90
When applied to inside-out membrane patches expressing rat TRPA1, URB597 elicited single-channel activities with a unitary conductance of 40 pS.
Gene_expression (expressing) of URB597
2) Confidence 0.02 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17314320 Disease Relevance 0.20 Pain Relevance 0.25
Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).
Gene_expression (profile) of URB597 associated with analgesic
3) Confidence 0.00 Published 2006 Journal CNS Drug Rev Section Title Doc Link 16834756 Disease Relevance 0.23 Pain Relevance 0.42

General Comments

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