INT136934

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.53
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Urb1)
Anatomy Link Frequency
tail 2
Urb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endocannabinoid 16 100.00 Very High Very High Very High
antinociception 2 99.48 Very High Very High Very High
tail-flick 9 99.40 Very High Very High Very High
Cannabinoid 9 98.76 Very High Very High Very High
agonist 3 98.74 Very High Very High Very High
Hyperalgesia 5 98.40 Very High Very High Very High
antagonist 5 97.48 Very High Very High Very High
Pain 11 95.88 Very High Very High Very High
Antinociceptive 3 90.84 High High
Thermal hyperalgesia 1 66.80 Quite High
Disease Link Frequency Relevance Heat
Gallstones 10 99.12 Very High Very High Very High
Hyperalgesia 6 98.40 Very High Very High Very High
Diabetes Mellitus 9 97.76 Very High Very High Very High
Pain 7 95.88 Very High Very High Very High
Nociception 9 75.76 Quite High
Hyperglycemia 1 72.36 Quite High
Body Weight 1 57.16 Quite High
Cv Unclassified Under Development 2 50.00 Quite Low
Ocular Hypertension 2 50.00 Quite Low
Ganglion Cysts 1 47.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats.
Negative_regulation (inhibitor) of URB597 associated with endocannabinoid, hyperalgesia and diabetes mellitus
1) Confidence 0.36 Published 2009 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 19526037 Disease Relevance 1.33 Pain Relevance 0.73
These data showed that URB597 as a FAAH inhibitor potentiates antinociception induced by cholestasis in tail-flick test and that the inhibitory effects of URB597 in this model are mediated by cannabinoid CB(1) and not CB(2) receptors.
Negative_regulation (inhibitor) of URB597 in tail associated with antinociception, cannabinoid, tail-flick and gallstones
2) Confidence 0.20 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18593578 Disease Relevance 0.56 Pain Relevance 0.72
These data showed that URB597 as a FAAH inhibitor potentiates antinociception induced by cholestasis in tail-flick test and that the inhibitory effects of URB597 in this model are mediated by cannabinoid CB(1) and not CB(2) receptors.
Negative_regulation (effects) of URB597 in tail associated with antinociception, cannabinoid, tail-flick and gallstones
3) Confidence 0.17 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18593578 Disease Relevance 0.49 Pain Relevance 0.62
In a search for novel TRPA1 agonists, we identified 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597), a potent and systemically active inhibitor of fatty acid amide hydrolase (FAAH).
Negative_regulation (inhibitor) of URB597 associated with agonist
4) Confidence 0.03 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17314320 Disease Relevance 0.15 Pain Relevance 0.21
Systemic administration of a specific FAAH inhibitor (e.g., URB597) reduced enzyme activity and minimized the retinal damage observed in ischemic-reperfused samples.
Negative_regulation (inhibitor) of URB597
5) Confidence 0.01 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17591864 Disease Relevance 0 Pain Relevance 0
In the present article, we review the pharmacological properties of KDS-4103 (URB597), a highly potent and selective inhibitor of the enzyme fatty-acid amide hydrolase (FAAH), which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide.
Negative_regulation (inhibitor) of URB597 associated with endocannabinoid
6) Confidence 0.00 Published 2006 Journal CNS Drug Rev Section Abstract Doc Link 16834756 Disease Relevance 0 Pain Relevance 0.11

General Comments

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