INT136941

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.42
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkce) Golgi apparatus (Prkce) endoplasmic reticulum (Prkce)
enzyme binding (Prkce) cytoplasm (Prkce) cytosol (Prkce)
Anatomy Link Frequency
plasma 2
neurons 2
Prkce (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 7 100.00 Very High Very High Very High
qutenza 6 98.20 Very High Very High Very High
antagonist 1 95.60 Very High Very High Very High
Pain 4 91.84 High High
Root ganglion neuron 2 88.24 High High
Hyperalgesia 8 86.40 High High
analgesia 1 85.92 High High
Lasting pain 1 85.04 High High
Kinase C 3 81.84 Quite High
nociceptor 6 70.64 Quite High
Disease Link Frequency Relevance Heat
Nociception 4 98.52 Very High Very High Very High
Pain 2 91.84 High High
Ganglion Cysts 2 87.84 High High
Herpes Simplex Virus 1 87.32 High High
Hyperalgesia 8 86.40 High High
INFLAMMATION 2 56.76 Quite High
Neuropathic Pain 1 55.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, estrogen applied alone leads to a brief translocation of PKCepsilon.
Positive_regulation (leads) of Localization (translocation) of PKCepsilon
1) Confidence 0.43 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16836642 Disease Relevance 0.67 Pain Relevance 0.46
We found estrogen-induced as well as GPR30-agonist-induced PKCepsilon translocation to be restricted to the subgroup of nociceptive neurons positive for isolectin IB4 from Bandeiraea simplicifolia.
Positive_regulation (estrogen-induced) of Localization (translocation) of PKCepsilon in neurons associated with nociception and agonist
2) Confidence 0.14 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18371086 Disease Relevance 0.33 Pain Relevance 0.68
Phorbol esters induced translocation of endogenous PKCepsilon to the plasma membrane and thereby enhanced CAPS currents.
Positive_regulation (induced) of Localization (translocation) of PKCepsilon in plasma associated with qutenza
3) Confidence 0.11 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973552 Disease Relevance 0.43 Pain Relevance 0.92

General Comments

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