INT136943

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Rapgef3)
Rapgef3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 4 98.00 Very High Very High Very High
cINOD 1 63.24 Quite High
Inflammatory mediators 1 44.44 Quite Low
Neuropathic pain 1 42.44 Quite Low
Inflammation 1 41.32 Quite Low
nociceptor 3 39.48 Quite Low
Kinase C 1 35.40 Quite Low
ischemia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 9 98.40 Very High Very High Very High
Hyperalgesia 4 98.00 Very High Very High Very High
Nociception 3 91.12 High High
Cardiovascular Disease 1 65.24 Quite High
INFLAMMATION 3 63.00 Quite High
Myocardial Infarction 1 54.76 Quite High
Neuropathic Pain 1 42.44 Quite Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, injection of estrogen preceding the activation of Epac completely abrogates the Epac-induced mechanical hyperalgesia.
Positive_regulation (activation) of Epac associated with hyperalgesia
1) Confidence 0.67 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16836642 Disease Relevance 0.49 Pain Relevance 0.27
Roflumilast increased Epac1/GTP-Rap1 and the protective effect was abolished by Epac1 siRNA transfection, demonstrating that Epac signaling was also involved in this protective response.
Positive_regulation (increased) of Epac1
2) Confidence 0.05 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18276108 Disease Relevance 0.77 Pain Relevance 0.06

General Comments

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