INT136964

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 3.69
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Dmp1) nucleolus (Dmp1) proteinaceous extracellular matrix (Dmp1)
nucleus (Dmp1) extracellular matrix organization (Dmp1) cytoplasm (Dmp1)
Anatomy Link Frequency
small intestine 3
ileum 2
osteoblasts 2
osteocyte 2
urine 1
Dmp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dextromethorphan 17 100.00 Very High Very High Very High
substance P 88 99.76 Very High Very High Very High
Serotonin 16 99.60 Very High Very High Very High
Somatostatin 12 98.32 Very High Very High Very High
tetrodotoxin 16 95.44 Very High Very High Very High
antagonist 24 92.00 High High
Cholecystokinin 8 91.52 High High
Neurotransmitter 48 90.64 High High
lidocaine 1 78.88 Quite High
adenocard 8 32.04 Quite Low
Disease Link Frequency Relevance Heat
Rickets 292 100.00 Very High Very High Very High
Hypercalcemia 12 94.76 High High
Hypophosphatemia 44 88.56 High High
Cancer 48 80.88 Quite High
Paraneoplastic Syndromes 4 77.12 Quite High
Overdose 1 76.00 Quite High
Ossifying Fibroma 4 66.72 Quite High
Disease 40 51.36 Quite High
Congenital Anomalies 12 41.44 Quite Low
Syndrome 16 35.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As with PHEX and FGF23, DMP1 is highly expressed in cells of the osteoblasts/osteocyte lineage.
Gene_expression (expressed) of DMP1 in osteoblasts
1) Confidence 0.75 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.44 Pain Relevance 0
It is of interest that the mRNA of all three factors (FGF23, PHEX and DMP1) involved in the pathogenesis of hypophosphataemic rickets are highly expressed in cells of the osteoblasts/osteocyte lineage.
Gene_expression (expressed) of DMP1 in osteocyte associated with rickets
2) Confidence 0.58 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.37 Pain Relevance 0
For the detection of DMP/DTP, urine samples were adjusted with 6N NaOH (pH 11) and extracted with ethylacetate.
Gene_expression (detection) of DMP in urine associated with dextromethorphan
3) Confidence 0.57 Published 2006 Journal Forensic Sci. Int. Section Abstract Doc Link 16837153 Disease Relevance 0.08 Pain Relevance 0.55
As with PHEX and FGF23, DMP1 is highly expressed in cells of the osteoblasts/osteocyte lineage.
Gene_expression (expressed) of DMP1 in osteocyte
4) Confidence 0.26 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.44 Pain Relevance 0
It is of interest that the mRNA of all three factors (FGF23, PHEX and DMP1) involved in the pathogenesis of hypophosphataemic rickets are highly expressed in cells of the osteoblasts/osteocyte lineage.
Gene_expression (expressed) of DMP1 in osteoblasts associated with rickets
5) Confidence 0.20 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.37 Pain Relevance 0
It has also been shown that ICC-DMP express muscarinic M2 receptor (Fig. 3) [21] and somatostatin 2A receptor [41].
Gene_expression (express) of ICC-DMP associated with somatostatin
6) Confidence 0.06 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1779949 Disease Relevance 0 Pain Relevance 0.26
Serotonin 5-HT3 receptor was expressed in both ICC-DMP and ICC-MY in the rat ileum [12].
Gene_expression (expressed) of ICC-DMP in ileum associated with serotonin
7) Confidence 0.05 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1779949 Disease Relevance 0 Pain Relevance 0.29
Serotonin 5-HT4 receptor was detected in both ICC-DMP and ICC-MY in the murine small intestine [26].
Gene_expression (detected) of ICC-DMP in small intestine associated with serotonin
8) Confidence 0.05 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1779949 Disease Relevance 0 Pain Relevance 0.29
In the murine ileum, almost all ICC-DMP were closely apposed to substance P containing nerve fibers and all ICC-DMP expressed NK1 receptor on their surface (Fig. 4) [19].
Gene_expression (expressed) of ICC-DMP in ileum associated with substance p
9) Confidence 0.04 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1779949 Disease Relevance 0 Pain Relevance 0.43
ICC-DMP are present in the small intestine, and distributed between the inner and outer parts of the circular muscle layer at the level of the deep muscular plexus (DMP).
Gene_expression (present) of ICC-DMP in small intestine
10) Confidence 0.04 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1779949 Disease Relevance 0 Pain Relevance 0
Purinergic P2Y4 receptor was expressed in guinea pig ICC-IM, ICC-DMP and ICC-MY [46].
Gene_expression (expressed) of ICC-DMP
11) Confidence 0.04 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1779949 Disease Relevance 0 Pain Relevance 0.29
A well-studied receptor is neurokinin 1 (NK1) receptor (substance P receptor), expressed in the ICC-DMP of the small intestine (see review [7]).
Gene_expression (expressed) of ICC-DMP in small intestine associated with substance p
12) Confidence 0.04 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1779949 Disease Relevance 0 Pain Relevance 0.23
expression in ICC-DMP [49].
Gene_expression (expression) of ICC-DMP
13) Confidence 0.04 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1779949 Disease Relevance 0 Pain Relevance 0.48

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