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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2) DNA binding (Nr1i2)
Anatomy Link Frequency
Nr1i2 (Mus musculus)
Pain Link Frequency Relevance Heat
methadone 5 100.00 Very High Very High Very High
Central nervous system 6 99.52 Very High Very High Very High
Antinociceptive 1 91.68 High High
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, hPXR activation in vivo increased P-glycoprotein activity and tightened the blood-brain barrier to methadone, reducing the drug's CNS efficacy.
Negative_regulation (reducing) of Positive_regulation (activation) of hPXR in CNS associated with central nervous system and methadone
1) Confidence 0.48 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16837625 Disease Relevance 0.33 Pain Relevance 0.72

General Comments

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