INT136981

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 3.63
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2) DNA binding (Nr1i2)
Anatomy Link Frequency
intestine 6
liver 2
brain 2
bile 2
Nr1i2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 99 99.46 Very High Very High Very High
Bile 429 96.76 Very High Very High Very High
methadone 5 83.28 Quite High
Central nervous system 6 82.56 Quite High
Antinociceptive 1 73.44 Quite High
carbamazepine 11 47.76 Quite Low
dexamethasone 22 46.64 Quite Low
antiepileptic Drug 11 45.60 Quite Low
Taxol 22 42.24 Quite Low
Inflammation 187 36.32 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 191 99.52 Very High Very High Very High
Osteogenic Sarcomas 55 99.32 Very High Very High Very High
Apoptosis 55 97.64 Very High Very High Very High
Rickets 88 97.56 Very High Very High Very High
Endometriosis (extended) 33 93.00 High High
Osteoporosis 77 92.92 High High
Cancer 198 78.48 Quite High
Toxicity 44 73.88 Quite High
Stress 11 58.52 Quite High
Hepatotoxicity 22 57.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, SXR overexpression causes significant decrease in cell growth inhibition and apoptosis mediated by these agents [Masuyama et al., 2007].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SXR associated with apoptosis
1) Confidence 0.65 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.66 Pain Relevance 0
Feeding mice with cholic acid or the synthetic FXR agonist GW4064 resulted in strong induction of SXR expression.
Positive_regulation (induction) of Gene_expression (expression) of SXR associated with agonist
2) Confidence 0.65 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.17 Pain Relevance 0.35
Vitamin K2 bound to and activated SXR and induced expression of the SXR target genes in osteosarcoma cells.
Positive_regulation (induced) of Gene_expression (expression) of SXR associated with osteogenic sarcomas
3) Confidence 0.65 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.66 Pain Relevance 0
This suggests that enhanced CYP24 expression by SXR is unlikely to play an important role in the development of osteomalacia following long-term treatment with SXR activators.
Positive_regulation (enhanced) of Gene_expression (expression) of SXR associated with rickets
4) Confidence 0.47 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.40 Pain Relevance 0
Vitamin K2 bound to and activated SXR and induced expression of the SXR target genes in osteosarcoma cells.
Positive_regulation (induced) of Gene_expression (expression) of SXR associated with osteogenic sarcomas
5) Confidence 0.47 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.61 Pain Relevance 0
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Positive_regulation (induced) of Gene_expression (expression) of SXR in intestine
6) Confidence 0.47 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.05
Activation of SXR downregulated expression of CYP7A1, the first and rate limiting step in the metabolism of cholesterol to bile acids [Staudinger et al., 2001; Xie et al., 2001].
Positive_regulation (Activation) of Gene_expression (expression) of SXR in bile associated with bile
7) Confidence 0.47 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.36 Pain Relevance 0.36
P-glycoprotein expression and transport activity in brain capillaries from transgenic mice was significantly increased when capillaries were exposed to the hPXR ligands, rifampin and hyperforin, in vitro and when the mice were dosed with rifampin in vivo.
Positive_regulation (increased) of Gene_expression (exposed) of hPXR in brain associated with targeted disruption
8) Confidence 0.41 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16837625 Disease Relevance 0.33 Pain Relevance 0.49
Therefore, the cytotoxic effects of SXR in combination with oxidative stressors such as paraquat needs to be further investigated.
Positive_regulation (effects) of Gene_expression (effects) of SXR
9) Confidence 0.41 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.12 Pain Relevance 0.04
In addition to these two models, Xie et al. and Gong et al. also generated Alb- and Fatty Acid-Binding Protein (FABP)-activated hSXR (VP-hSXR) mice in which constitutively activated hSXR were expressed in the liver (Alb promoter driven) or in the liver and intestine (FABP promoter driven), respectively [Gong et al., 2006; Xie et al., 2000a] .
Positive_regulation (generated) of Gene_expression (expressed) of hSXR in intestine
10) Confidence 0.38 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Positive_regulation (induced) of in liver Gene_expression (expression) of SXR in intestine
11) Confidence 0.16 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.05
In addition to these two models, Xie et al. and Gong et al. also generated Alb- and Fatty Acid-Binding Protein (FABP)-activated hSXR (VP-hSXR) mice in which constitutively activated hSXR were expressed in the liver (Alb promoter driven) or in the liver and intestine (FABP promoter driven), respectively [Gong et al., 2006; Xie et al., 2000a] .
Positive_regulation (generated) of in liver Gene_expression (expressed) of hSXR in intestine
12) Confidence 0.13 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0

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