INT136991

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.62
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (HBEGF) extracellular space (HBEGF) extracellular region (HBEGF)
plasma membrane (HBEGF)
Anatomy Link Frequency
BUC 1
Keratinocytes 1
HBEGF (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 12 99.80 Very High Very High Very High
adenocard 1 93.28 High High
metalloproteinase 10 91.60 High High
cytokine 6 67.52 Quite High
Hyperalgesia 1 66.36 Quite High
Inflammation 4 20.48 Low Low
ischemia 2 16.64 Low Low
imagery 6 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
pruritus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diphtheria 14 100.00 Very High Very High Very High
Injury 132 99.96 Very High Very High Very High
Interstitial Cystitis 12 99.80 Very High Very High Very High
Cancer 21 95.76 Very High Very High Very High
Death 4 93.68 High High
Wound Healing 32 88.32 High High
Adhesions 6 83.20 Quite High
Metastasis 2 77.60 Quite High
Targeted Disruption 2 77.28 Quite High
Congenital Anomalies 2 69.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of IC BUC with heparin-binding epidermal growth factor-like growth factor (HB-EGF), previously shown to be secreted in lower amounts by IC BUC, significantly increased inward potassium current.
Localization (secreted) of heparin-binding epidermal growth factor-like growth factor in BUC associated with interstitial cystitis
1) Confidence 0.59 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837648 Disease Relevance 1.03 Pain Relevance 1.07
In response to injury, HbEGF is cleaved and released by extracellular MMP-3, or Stromelysin I.15 Keratinocytes also produce MMP-1, MMP-2 and MMP-9, all of which help to remodel the matrix, allowing cells to migrate into and close the wound.9,16–18 MMP production is stimulated by the presence of target substrates and growth factors,.9,16,19–21 and MMP-1 can also be bound by integrin ?
Localization (released) of HbEGF in Keratinocytes associated with injury
2) Confidence 0.33 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501117 Disease Relevance 0.91 Pain Relevance 0.09
It has been shown in vitro that stromelysin, or MMP-3,15 is able to cleave HbEGF at the juxtamembrane site, releasing the mature, soluble form of the growth factor to signal in a paracrine or juxtacrine fashion.
Localization (releasing) of HbEGF
3) Confidence 0.33 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501117 Disease Relevance 0.44 Pain Relevance 0.04
Diphtheria toxin is secreted from Corynebacterium diphtheriae as a single polypeptide chain containing two major domains: A chain (amino-terminal, 193 residues), which carries the active site for adenosine diphosphate (ADP)-ribosylation of elongation factor-2, and B chain (carboxyl-terminal, 342 residues), which promotes binding of toxin to cells and the entry of the A chain into the cytosolic compartment.
Localization (secreted) of Diphtheria toxin associated with adenocard and diphtheria
4) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918631 Disease Relevance 0.69 Pain Relevance 0.05
The fragment of diphtheria toxin is translocated across the endosomal membrane into the cytosol where it inhibits protein synthesis via ADP-ribosylation of elongation factor-2, ultimately resulting in cell death.9,10
Localization (translocated) of diphtheria toxin associated with diphtheria and death
5) Confidence 0.01 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.54 Pain Relevance 0.03

General Comments

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