INT137007

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.53
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMAD2) nucleoplasm (SMAD2) nucleus (SMAD2)
intracellular (SMAD2) DNA binding (SMAD2) transcription factor binding (SMAD2)
Anatomy Link Frequency
quadriceps 1
PSCs 1
epithelial cells 1
SMAD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 22 97.80 Very High Very High Very High
fibrosis 26 86.80 High High
COX-2 inhibitor 2 84.36 Quite High
Chronic pancreatitis 8 67.60 Quite High
Inflammation 50 63.12 Quite High
Inflammatory response 12 62.32 Quite High
COX2 2 25.00 Low Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 103 99.60 Very High Very High Very High
Primary Sclerosing Cholangitis 6 95.04 Very High Very High Very High
Pancreatic Cancer 57 92.72 High High
Fibrosis 24 86.80 High High
Hypertrophy 36 77.04 Quite High
Pancreatitis 8 67.60 Quite High
Colon Cancer 2 63.44 Quite High
INFLAMMATION 64 63.12 Quite High
Injury 24 47.24 Quite Low
Stress 7 46.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, dominant negative Smad2/3 expression attenuated the expression of COX-2 and alpha-SMA enhanced by IL-1beta and IL-6.
Gene_expression (expression) of Smad2
1) Confidence 0.75 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.40 Pain Relevance 0.27
Adenovirus-mediated expression of dominant negative Smad2/3 inhibited the increase in expression of COX-2, alpha-SMA, and collagen-1 mediated by TGF-beta1 in activated PSCs.
Gene_expression (expression) of Smad2 in PSCs
2) Confidence 0.75 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.42 Pain Relevance 0.29
Immunohistochemistry (Smad3 And p-Smad2/3)
Gene_expression (/) of Smad2
3) Confidence 0.65 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0 Pain Relevance 0
In C57 Bl/6 mice overexpressing dnMstat there was a decrease in the levels of phosphorylated Smad 2/3 as was seen in C2C12 cells incubated with anti-myostatin antibody [3].
Gene_expression (overexpressing) of Smad 2
4) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.08 Pain Relevance 0
In treated quadriceps there was a decrease in phosphorylated Smad 2/3, a decrease in phosphorylated JNK and an increase in phosphorylated Akt (n?
Gene_expression (/) of Smad 2 in quadriceps
5) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0 Pain Relevance 0
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Gene_expression (expression) of Smad2 in epithelial cells
6) Confidence 0.58 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.76 Pain Relevance 0.11
With time, the fraction of positively staining cells also increased in XRT-TG animals but this p-Smad2/3 expression was significantly diminished when compared with XRT-WT.
Gene_expression (expression) of Smad2 associated with targeted disruption
7) Confidence 0.58 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.87 Pain Relevance 0.07

General Comments

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