INT137008

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.51
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMAD2) nucleoplasm (SMAD2) nucleus (SMAD2)
intracellular (SMAD2) DNA binding (SMAD2) transcription factor binding (SMAD2)
Anatomy Link Frequency
PSCs 2
SMAD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 98.60 Very High Very High Very High
COX-2 inhibitor 1 85.16 High High
Chronic pancreatitis 2 68.40 Quite High
Inflammatory response 1 63.12 Quite High
COX2 1 25.00 Low Low
ketamine 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 3 95.84 Very High Very High Very High
Hypertrophy 18 77.04 Quite High
Pancreatitis 2 68.40 Quite High
INFLAMMATION 1 62.72 Quite High
Muscular Dystrophy 17 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Hyperplasia 9 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Dilated Cardiomyopathy 5 5.00 Very Low Very Low Very Low
Coronary Heart Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adenovirus-mediated expression of dominant negative Smad2/3 inhibited the increase in expression of COX-2, alpha-SMA, and collagen-1 mediated by TGF-beta1 in activated PSCs.
Positive_regulation (Adenovirus-mediated) of Gene_expression (expression) of Smad2 in PSCs
1) Confidence 0.49 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.43 Pain Relevance 0.30
In C57 Bl/6 mice overexpressing dnMstat there was a decrease in the levels of phosphorylated Smad 2/3 as was seen in C2C12 cells incubated with anti-myostatin antibody [3].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Smad 2
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.08 Pain Relevance 0

General Comments

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