INT137009

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.76
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMAD2) nucleoplasm (SMAD2) nucleus (SMAD2)
intracellular (SMAD2) DNA binding (SMAD2) transcription factor binding (SMAD2)
Anatomy Link Frequency
quadriceps 2
PSCs 2
SMAD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 14 97.80 Very High Very High Very High
fibrosis 13 89.12 High High
COX-2 inhibitor 2 84.36 Quite High
Chronic pancreatitis 4 67.60 Quite High
Inflammation 25 65.44 Quite High
Inflammatory response 7 62.32 Quite High
COX2 2 25.00 Low Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 50 99.60 Very High Very High Very High
Primary Sclerosing Cholangitis 6 95.04 Very High Very High Very High
Fibrosis 12 89.12 High High
Pancreatitis 4 67.60 Quite High
INFLAMMATION 33 65.44 Quite High
Stress 3 48.48 Quite Low
Injury 12 47.24 Quite Low
Lifespan 2 39.52 Quite Low
Edema 3 30.88 Quite Low
Hypertrophy 18 28.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With time, the fraction of positively staining cells also increased in XRT-TG animals but this p-Smad2/3 expression was significantly diminished when compared with XRT-WT.
Negative_regulation (diminished) of Gene_expression (expression) of Smad2 associated with targeted disruption
1) Confidence 0.42 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.93 Pain Relevance 0.10
Adenovirus-mediated expression of dominant negative Smad2/3 inhibited the increase in expression of COX-2, alpha-SMA, and collagen-1 mediated by TGF-beta1 in activated PSCs.
Negative_regulation (inhibited) of Gene_expression (expression) of Smad2 in PSCs
2) Confidence 0.41 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.43 Pain Relevance 0.29
Moreover, dominant negative Smad2/3 expression attenuated the expression of COX-2 and alpha-SMA enhanced by IL-1beta and IL-6.
Negative_regulation (attenuated) of Gene_expression (expression) of Smad2
3) Confidence 0.41 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.40 Pain Relevance 0.27
In treated quadriceps there was a decrease in phosphorylated Smad 2/3, a decrease in phosphorylated JNK and an increase in phosphorylated Akt (n?
Negative_regulation (decrease) of Gene_expression (/) of Smad 2 in quadriceps
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0 Pain Relevance 0

General Comments

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