INT137016

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.75
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
cytoskeleton (Acta2) cytoplasm (Acta2)
Anatomy Link Frequency
PSCs 2
Il6 (Rattus norvegicus)
Acta2 (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 2 96.12 Very High Very High Very High
cytokine 6 87.04 High High
Chronic pancreatitis 4 79.36 Quite High
Inflammatory response 2 74.08 Quite High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 6 94.84 High High
Pancreatitis 4 79.36 Quite High
INFLAMMATION 2 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NS-398 also inhibited the enhancement of alpha-SMA expression by TGF-beta1, IL-1beta, and IL-6 in activated PSCs.
IL-6 Positive_regulation (enhancement) of Gene_expression (expression) of alpha-SMA in PSCs
1) Confidence 0.01 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.42 Pain Relevance 0.32
Anti-TGF-beta neutralizing antibody also attenuated the increase in COX-2 and alpha-SMA expression caused by IL-1beta and IL-6.
IL-6 Positive_regulation (caused) of Gene_expression (expression) of alpha-SMA
2) Confidence 0.00 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.34 Pain Relevance 0.22

General Comments

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