INT137023

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (SMAD2, Acta2) nucleoplasm (SMAD2) intracellular (SMAD2)
DNA binding (SMAD2) cytosol (SMAD2) nucleus (SMAD2)
Anatomy Link Frequency
PSCs 3
SMAD2 (Homo sapiens)
Acta2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 3 97.80 Very High Very High Very High
COX-2 inhibitor 1 84.36 Quite High
Chronic pancreatitis 2 67.60 Quite High
Inflammatory response 1 62.32 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 3 95.04 Very High Very High Very High
Pancreatitis 2 67.60 Quite High
INFLAMMATION 1 61.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adenovirus-mediated expression of dominant negative Smad2/3 inhibited the increase in expression of COX-2, alpha-SMA, and collagen-1 mediated by TGF-beta1 in activated PSCs.
Gene_expression (expression) of Smad2 in PSCs Negative_regulation (inhibited) of Gene_expression (expression) of alpha-SMA in PSCs
1) Confidence 0.00 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.43 Pain Relevance 0.29

General Comments

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