INT13703

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Context Info
Confidence 0.23
First Reported 1984
Last Reported 2009
Negated 2
Speculated 2
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.92
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Phc1) DNA binding (Phc1)
Anatomy Link Frequency
smooth muscle 1
Impression 1
Phc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 10 100.00 Very High Very High Very High
Analgesic 5 99.98 Very High Very High Very High
Clonidine 18 99.84 Very High Very High Very High
anesthesia 8 98.86 Very High Very High Very High
cocaine 10 97.84 Very High Very High Very High
addiction 6 97.52 Very High Very High Very High
methadone 2 97.12 Very High Very High Very High
Nicotine 2 94.52 High High
alcohol 6 93.80 High High
Dopamine 104 90.52 High High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 367 98.72 Very High Very High Very High
Cocaine Dependence 4 97.84 Very High Very High Very High
Substance Abuse 34 97.60 Very High Very High Very High
Recurrence 2 95.72 Very High Very High Very High
Nicotine Addiction 2 95.08 Very High Very High Very High
Depression 8 84.96 Quite High
Anxiety Disorder 11 77.04 Quite High
Manic Depressive Disorder 2 76.16 Quite High
Psychosis 9 75.44 Quite High
Cognitive Disorder 27 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clonidine had no effect on the EDR evoked at the periphery but produced a significant dose-dependent depressant effect on the centrally evoked EDR; this effect was partially antagonized by yohimbine (0.75 mg/kg).
Neg (no) Regulation (effect) of EDR associated with clonidine
1) Confidence 0.23 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6143676 Disease Relevance 0 Pain Relevance 0.10
It is concluded that 1) Anesthesia of the animals and cold storage of the preparations can alter the EDR even in the absence of contractile changes in the smooth muscle, and 2) Accumulation of endothelin during the incubation period, even if not producing changes in the resting tension, can substantially alter the subsequent response to vasoactive interventions.
Regulation (alter) of EDR in smooth muscle associated with anesthesia
2) Confidence 0.12 Published 2001 Journal Endothelium Section Abstract Doc Link 11824475 Disease Relevance 0 Pain Relevance 0.24
Repeated contractions with norepinephrine (NE) 0.1 microM after stabilization altered neither the contraction nor the EDR induced by acetylcholine (Ach) 1 microM.
Neg (neither) Regulation (altered) of EDR
3) Confidence 0.12 Published 2001 Journal Endothelium Section Abstract Doc Link 11824475 Disease Relevance 0 Pain Relevance 0.24
To examine the effects of low, clinically relevant MPH doses on PFC function in rats, Arnsten and Dudley [2] tested the animals on a spatial delayed alteration task, a classical working memory task of PFC function in rodents.
Spec (examine) Regulation (effects) of MPH
4) Confidence 0.07 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0.60 Pain Relevance 0.51
In one study, long-acting MPH was shown to be effective in controlling the symptoms of ADHD in patients with cocaine dependence in complete remission without any relapse of abuse.33 Interestingly, a 14-week trial comparing the efficacy of sustained-release MPH to placebo in the treatment of cocaine-dependent adults with ADHD failed to demonstrate a significant reduction in ADHD symptoms, but did result in a reduction in cocaine use among MPH-treated patients.65 However, MPH is still considered a second line agent for treatment of patients with adult ADHD and comorbid substance abuse disorder who do not respond to antidepressants or atomoxetine.
Regulation (effective) of MPH associated with addiction, antidepressant, drug abuse, attention deficit hyperactivity disorder, recurrence and cocaine
5) Confidence 0.03 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732009 Disease Relevance 1.53 Pain Relevance 0.40
In a 7-week randomized controlled trial, adult ADHD symptom reduction as measured by the Clinical Global Impression scale was 50% for methylphenidate, 64% for sustained-release bupropion and 27% for placebo.67 A 12-week trial comparing the efficacy of sustained-release MPH or sustained-release bupropion to placebo in treating ADHD symptoms in methadone-maintained subjects with cocaine dependence or abuse did not show any significant difference between treatments because of a high placebo response.
Regulation (efficacy) of MPH in Impression associated with addiction, methadone, attention deficit hyperactivity disorder and cocaine
6) Confidence 0.02 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732009 Disease Relevance 1.49 Pain Relevance 0.59
To examine the effect of the RT variability on the MPH treatment response, we carried out analysis in two phases.
Spec (examine) Regulation (effect) of MPH
7) Confidence 0.02 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768239 Disease Relevance 0.23 Pain Relevance 0
We have previously described the peripheral analgesic effect of dibutyryl cyclic GMP, acetylcholine (ACh) and morphine (Mph) injected into the rat paws.
Regulation (effect) of Mph associated with analgesic and morphine
8) Confidence 0.01 Published 1991 Journal Agents Actions Suppl. Section Abstract Doc Link 1676874 Disease Relevance 0.07 Pain Relevance 0.63

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